Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

Published by BioScientifica
Previous issue | Volume 34 | SFEBES2014 | Next issue

Society for Endocrinology BES 2014

Symposia

GNRH biology ‐ from pulses to longevity (Supported by <emphasis role="italic">Journal of Molecular Endocrinology</emphasis>)

Table of contents
Next section
The upside of glucocorticoids in metabolism (Supported by Journal of Endocrinology)

ea0034s1.1 | GNRH biology ‐ from pulses to longevity (Supported by <emphasis role="italic">Journal of Molecular Endocrinology</emphasis>) | SFEBES2014

Systems approaches to understanding GnRH signalling

Perrett Rebecca , Voliotis Margaritis , Armstrong Stephen , Pope George , Tsaneva-Atanasova Krasimira , McArdle Craig

GnRH acts via Gq/11-coupled GPCRs on gonadotropes to control synthesis and secretion of LH and FSH. We use mathematical and statistical approaches as well as automated cell imaging to explore this system. In cells expressing ERK2–GFP and GnRH receptors, GnRH pulses cause rapid and transient nuclear translocation of ERK2–GFP, providing a live-cell readout for ERK activation1. A mathematical model trained against this data predicted greater sensitivity to re...
0 shares

ea0034s1.2 | GNRH biology ‐ from pulses to longevity (Supported by <emphasis role="italic">Journal of Molecular Endocrinology</emphasis>) | SFEBES2014

Abstract unavailable....
0 shares

ea0034s1.3 | GNRH biology ‐ from pulses to longevity (Supported by <emphasis role="italic">Journal of Molecular Endocrinology</emphasis>) | SFEBES2014

GnRH and inflammatory signalling in the ageing hypothalamus

Cai Dongsheng

In this talk, I will discuss the integrated role of hypothalamic inflammation and GnRH dysfunction in the development of systemic aging. First, I will provide an overview on aging-related profiles of hypothalamic pro-inflammatory NF-kB pathway as well as GnRH change. Second, I will describe how these changes can employ a neurodegenerative mechanism, in particular through targeting hypothalamic neural stem cells, to mediate the pathogenesis of aging and many aging-related disor...
0 shares

Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 | Privacy policy | Cookie settings

BiosciAbstracts

Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.

Find out more