Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 34 | SFEBES2014 | Next issue

Society for Endocrinology BES 2014

Symposia

Emerging Clinical importance of iodine (Supported by <emphasis role="italic">Endocrine-Related Cancer</emphasis>)

ea0034s3.1 | Emerging Clinical importance of iodine (Supported by <emphasis role="italic">Endocrine-Related Cancer</emphasis>) | SFEBES2014

Inadequate iodine status in UK pregnant women adversely affects cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Rayman Margaret , Bath Sarah , Steer Colin , Golding Jean , Emmett Pauline

As a component of thyroid hormones, iodine is essential for the development of the fetus, particularly for brain development. Though there has been no awareness of a problem of iodine deficiency in the UK for many years, it is becoming increasingly apparent that mild-to-moderate iodine-deficient is now present in certain population sub-groups. We assessed whether such a level of deficiency in UK pregnant women could be having an adverse effect on cognition in their offspring u...

ea0034s3.2 | Emerging Clinical importance of iodine (Supported by <emphasis role="italic">Endocrine-Related Cancer</emphasis>) | SFEBES2014

Regulation of NIS function in thyroid and breast cancer

Brent Gregory

Expression of the sodium iodide symporter (NIS) protein, and correct membrane insertion, is required for efficient iodide uptake in thyroid and lactating breast. Radioactive iodide is routinely utilized to target remnant thyroid and metastasis after total thyroidectomy for thyroid cancer. Stimulation of NIS expression by high levels of TSH, however, is necessary to achieve radioiodide uptake into thyroid cancer sufficient for therapy. The majority of breast cancer also express...

ea0034s3.3 | Emerging Clinical importance of iodine (Supported by <emphasis role="italic">Endocrine-Related Cancer</emphasis>) | SFEBES2014

Use of radioiodine in the imaging and therapy of non-thyroidal tumors

Spitzweg Christine

As one of the oldest targets for molecular imaging and targeted radionuclide therapy, characterization of the sodium iodide symporter (NIS) as a novel reporter and suicide gene offers the possibility of NIS gene transfer in nonthyroidal tumors followed by diagnostic and therapeutic application of radioiodine. Our previous work has convincingly demonstrated the high efficacy of radionuclide therapy after tumor-selective NIS gene delivery. As logical consequence of our pioneer s...