Searchable abstracts of presentations at key conferences in endocrinology
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16th European Congress of Endocrinology

Plenary Lectures

Good times, bad times: (patho)physiology of diurnal rhythms

ea0035pl3 | Good times, bad times: (patho)physiology of diurnal rhythms | ECE2014

Good times, bad times: (patho)physiology of diurnal rhythms

van der Horst Gijsbertus (Bert)

Like most organisms, we have developed an internal time keeping system that drives daily rhythms in metabolism, physiology and behavior, and allows us to optimally anticipate to the momentum of the day. At the basis of circadian timekeeping lies an intracellular molecular oscillator in which a set of clock genes cyclically regulate their own expression with an approximate (circa) 24-h (dies) periodicity. The mammalian circadian system consists of a light-entrainable master clo...