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16th European Congress of Endocrinology

Poster Presentations

Adrenal Medulla

ea0035p57 | Adrenal Medulla | ECE2014

ACTH-producing pheochromocytoma presenting with Cushing's syndrome and complicated by invasive aspergillosis: a case report

Moon Jun Sung , Cho Jae Ho , Yoon Ji Sung , Won Kyu Chang , Lee Hyoung Woo

Introduction: ACTH-producing pheochromocytoma has been rarely reported, ranging from 3 to 25% of the ectopic ACTH syndrome. Moreover, a few cases of Cushing’s syndrome (CS) accompanied with opportunistic infections have been reported. We experienced a case of pheochromocytoma with ectopic CS, complicated by invasive aspergillosis.Case report: A 35-year-old woman visited our hospital because of headache for 2 months. She presented with typical cushin...

ea0035p58 | Adrenal Medulla | ECE2014

Pheochromocytomas and paragangliomas: association between tumor size and measurements of metanephrines and catecholamines

Luiz Henrique Vara , Silva Tiago Nunes da , Pereira Bernardo Dias , Veloza Andreia , Matos Ana Catarina , Manita Isabel , Cordeiro Maria Carlos , Raimundo Luisa , Portugal Jorge

Introduction: Pheochromocytomas (PHEO) and paragangliomas (PGL) are rare catecholamine-secreting tumors. Some authors proposed that there is a positive linear relationship between tumor size and measurements of metanephrines and an absence of association with catecholamine levels.Objectives: To review and characterize patients diagnosed with PHEO and PGL in Garcia de Orta Hospital. To determine the relationship between tumor size and measurements of urin...

ea0035p59 | Adrenal Medulla | ECE2014

The value of metanephrines and normetanephrines influences blood pressure in patients with pheochromocytoma?

Petris Rodica , Dumitrache Constantin , Paun Sorin , Poiana Catalina , Carsote Mara , Paun Diana

Catecholamines can cause hypertension by increasing heart rate and cardiac output or by peripheral vasoconstriction.Aim of study: The value of plasma and urinary metanephrines and normetanephrines does not correlate with blood pressure in pheochromocytomas.Material and methods: The lot of study consist of 35 patients with isolated pheochromocytomas diagnosed between 1985 and 2005 in National Institute of Endocrinology C.I.Parhon Bu...

ea0035p60 | Adrenal Medulla | ECE2014

Olygosimptomatic malignant pheochromocytoma treated with 131I-MIBG

Jercalau Simona , Gabur Alexandra , Hortopan Dan , Stefanescu Ana Maria , Dumitrascu Anda , Badiu Corin

Introduction: Pheochromocytomas are rarely malignant, defined by the presence of cathecholamine – producing metastases. Malignant pheochromocytoma responds poorly to chemotherapy and radiotherapy. 131I-MIBG therapy can be used to prolong survival, with minor side effects.Case: A 45-years old woman known with malignant pheochromocytoma, with a long medical history, first came to our clinic in July 2012. Her diagnosis was suspected in 1999 ...

ea0035p61 | Adrenal Medulla | ECE2014

A difficult case of ectopic Cushing's syndrome due to ACTH-producing pheochromocytoma presented with normal fractionated urinary catecholamines and metanephrines

Topaloglu Oya , Polat Sefika Burcak , Ogmen Berna Evranos , Baser Husniye , Dirikoc Merve , Tokac Mehmet , Sak Serpil Dizbay , Ersoy Reyhan , Cakir Bekir

Introduction: Ectopic ACTH secretion by pheochromocytoma causing Cushing’s syndrome has been reported rarely. Here, we present a patient with ectopic ACTH-dependent Cushing’s syndrome, caused by a pheochromocytoma with normal fractionated 24 h urinary catecholamines and metanephrines.Case report: A 48-year old female patient admitted to our clinics with the complaints of severe hypertension despite receiving anti hypertensive therapy. Severe he...

ea0035p62 | Adrenal Medulla | ECE2014

Expression of IGF/mTOR pathway components in human pheochromocytomas and in vitro inhibition of PC12 rat pheochromocytoma cell growth by mTOR inhibitors alone and in combination with the dual IGFI-R/INS-R antagonist OSI-906

Martino Maria Cristina De , Feelders Richard A. , Dogan Fadime , Koetsveld Peter M. van , Krijger Ronald R. De , Janssen Joseph A M J L , Sprij-Mooij Diana , Lamberts Steven W. J. , Herder Wouter W de , Colao Annamaria , Pivonello Rosario , Hofland Leo J

The mTOR and IGF pathways have been suggested to play a role in the pathogenesis of pheochromocytomas (PCC). mTOR inhibitors, as sirolimus (S) and everolimus (E), as well as IGF1R antagonists could be a potential novel treatment for malignant PPC.The aim of this study was to evaluate the expression of the main components of the IGF/mTOR pathway in human PCC and to investigate the effects of the mTOR inhibitors S and E and of the IGF1R/insulin receptor (I...

ea0035p63 | Adrenal Medulla | ECE2014

Asymptomatic catecholamine-producing tumours in Von Hipple–Lindau disease

Martins Ana Filipa , Martins Joao Martin , Vale Sonia do , Gomes Ana Raquel

Introduction: Von Hippel–Lindau disease (VHLD) is an autosomal dominant neoplastic syndrome characterized by the development of multiple cancers and cists, including pheochromocytoma and islet cell tumors. Screening is mandatory for family members of index cases.Case report: A 23-year-old male Caucasian was referred to Endocrine Department because of the recent genetic diagnosis of VHLD during familiar screening. The mutation c.482G>A(p.Arg161GI...

ea0035p64 | Adrenal Medulla | ECE2014

Analysis of pheochromocytomas/paragangliomas from Eastern Slovakia

Felsoci Marek , Lazurova Ivica , Wagnerova Hedviga , Svajdler Marian

This multi centre observational cohort study gives a view about the occurrence, clinical and laboratory presentation, localization, histological type and genetic background of pheochromocytoma (PHEO) and paraganglioma (PGL) in Eastern Slovakia. It included 28 patients (18 women +10 men), of which 23 were diagnosed to have PHEO (82.1%) and seven patients (25%) suffered from PGL with retroperitoneal, inguinal/pelvic and mediastinal distribution. Arterial hypertension was the maj...