Searchable abstracts of presentations at key conferences in endocrinology
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16th European Congress of Endocrinology

Poster Presentations

Cardiovascular Endocrinology & Lipid Metabolism

ea0035p169 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Cardiothyreosis: pathogenic conjectures, clinical aspects and surgical approach

Diaconescu Mihai Radu , Datcu Georgeta , Datcu Mihai Dan , Diaconescu Smaranda

Background: The presence of striking cardiovascular manifestations was noted in the first descriptions of hyperthyroidism owing to Parry (1825) and Basedow (1840) in the famous Merseburger triad. Hyperthyroidism may either cause cardiac complication in individuals with a normal myocardium (genuine form of disorder) or complicate pre-existing cardiac troubles.Patients and methods: An homogenous series of 49 cardiothyreosis, 11 males and 38 females, aged 1...

ea0035p170 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Polyphenol-rich dark chocolate lowers LDL oxidation without affecting high-sensitivity CRP levels in adults

Farhat Grace , Al-Dujaili Emad

Chronic inflammation and oxidative stress have been described as crucial factors in the pathogenesis of atherosclerosis and the occurrence of cardiovascular diseases (CVD). Polyphenols are phytochemicals with established antioxidant properties, and dark chocolate (DC), a highly consumed food, is one of main food sources of polyphenols. Many human studies have suggested a lowering effect of DC on oxidized LDL levels, while its impact on high sensitivity CRP (hs-CRP) -one of the...

ea0035p171 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Osteopontin, hs-CRP levels in gestational diabetes mellitus

Saklamaz Ali , Akyildiz Muhittin , Celik Esin , Genc Mine , Korkut Berrin , Yalcin Murat , Aykir Halil , Kirgiz Ozlem Ozenturk

Introduction: Gestational diabetes mellitus (GDM) is a sort of temporary carbonhydrate intolerance in pregnancy. GDM leads to a variety of risks for the fetus and the mother during pregnancy. Mothers who had GDM during their pregnancy have high risk of caesarean section and pre-eclampsia. Also there are risks of macrosomia, neonatal hypoglycemia and hyperbilirubinemia for the fetuses of these mothers. Cardiovascular disorders, hypertension, dyslipidemia and metabolic syndrome ...

ea0035p172 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Isotretinoin effect on osteopontin, hs-CRP, insulin sensitivity and CIMT in acne patients

Saklamaz Ali , Uyar Belkis , Solak Aynur , Akyildiz Muhittin , Genc Berhan , Gokduman Ayse , Yalcin Murat , Aykir Halil , Kirgiz Ozlem Ozenturk

Introduction: Isotretinoin (Iso) treatment in acne disease may cause dyslipidemia and increased liver enzymes. Its effects on lipid and glucose metabolism may cause atherogenic complications. The aim of this study was to evaluate carotis intima–media thickness (CIMT), HOMA-IR, and osteopontin (OPN) levels in acne patients on Iso treatment.Methods: Iso treatment given 21 patients are included in this study. They followed for 4 months. 21 patients wit...

ea0035p173 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

New vitamin D less-calcemic analog affects human bone cell line and cultured vascular smooth muscle cells similar to other analogs

Shishko Elena , Mokhort Tatyana

Aim: The aim of our study is to assess the efficacy of a lifestyle modification including altered diet composition and physical activity in preventing diabetes mellitus type 2 (DM2) in individuals with impaired glucose tolerance and impaired fasting glucose (IGT/IFG) and influence it on changes serum leptin levels.Materials and methods: The study included 327 patients with IGT/IFG (68 m, 258 f) 25-65 years. Patients were divided into two groups matched b...

ea0035p174 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Oxytocin prevents cardiomyocyte hypertrophy

Gutkowska Jolanta , Menouar Ahmed , Jankowski Marek

Aims/hypothesis: Oxytocin (OT) and OT receptor (OTR) are expressed in the heart. During OT synthesis, its precursor, termed OT-Gly-Lys-Arg (OT-GKR), is abundantly accumulated in the developing rat heart. Because the OTR is primarily associated with Gq/11protein subunit that activates protein synthesis, we hypothesised that OT can cause cardiomyocyte hypertrophy. On the other hand, OTR signalling is associated with anti-hypertrophic atrial natriuretic peptide (ANP) release and ...

ea0035p175 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Parameters of metabolic syndrome in prehypertensive subjects: should we be looking for them?

Chantziara Klio , Maniotis Christos , Kokkoris Panagiotis , Toloumis George

Introduction: Insulin resistance has been found to be higher in hypertensive subjects. Whether this is also true in prehypertension is controversial. We examined both insulin resistance and lipidemic profile in subjects with prehypertension.Methods: 214 outpatients (119 men and 97 women) of Greek origin were divided into two groups: i) prehypertensive and ii) control group. These groups were tested for insulin resistance using the HOMA-index, as well as ...

ea0035p176 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Serum and plasma aldosterone levels and the respective aldosterone/plasma renin indices in healthy blood donors

Glinicki Piotr , Jeske Wojciech , Kapuscinska Renata , Zgliczynski Wojciech

Introduction: Primary aldosteronism (PA) is one of the causes of hypertension. Blood aldosterone and the aldosterone/direct renin concentration (DRC) are routinely used as a screening test for PA.Aim of study: Whether it matters if aldosterone concentration is determined in serum or plasma samples?Material and methods: 145 healthy males, five females (blood donors) were investigated. In all subjects blood was collected into two tub...

ea0035p177 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Red wine increases SHBG production by HepG2 cells

Lopez Cristina Saez , Simo Rafael , Hernandez Cristina , Selva David Martinez

Low circulating sex hormone-binding globulin (SHBG) is an independent risk factor for cardiovascular disease. Mediterranean diet has been associated with a decreased risk of cardiovascular disease. We have recently shown that olive oil consumption is associated with elevated SHBG serum levels and that PPARγ downregulation induced by oleoyl-CoA is an important underlying mechanism of such regulation. Red wine is also an important component of the Mediterranean diet and its...

ea0035p178 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

New possible predictors of left ventricular hypertrophy

Postoeva Anna , Dvoryashina Irina , Bakhtina Zoya

Introduction: Left ventricular hypertrophy (LVH) in obesity cannot be explained only by increased body mass (BM), BMI, or arterial hypertension (AH). Aim was to investigate possible clinical or hormonal predictors of LVH.Materials and methods: We examined women before The Programme of Weight Loss. The echocardiography was performed; mass of myocardium of LV (MMLV), relative wall thickness (RWT) and indexed MMLV (IMMLV) by body surface area were calculate...

ea0035p179 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Characteristics of compensated hypogonadism in patients with sexual dysfunction

Corona Giovanni , Maseroli Elisa , Rastrelli Giulia , Maggi Mario

Introduction: In the last few years the view that subclinical endocrine disorders represent milder forms of the clinically overt disease has emerged. Accordingly, it has been proposed that compensated hypogonadism represents a genuine clinical subgroup of individuals with late onset hypogonadism (LOH). The aim of the present study is to investigate the association of compensated hypogonadism with clinical and psychological characteristics of male subjects complaining for sexua...

ea0035p180 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Blood levels of apelin in patients with essential hypertension and type 2 diabetes mellitus and its relationship with the duration of hypertension and anthropometric indices

Sergiy Koval , Kostiantyn Iushko , Tatiana Starchenko , Elena Vysotskaya , Anna Strashnenko

Introduction: Endogenous peptide apelin has profound hypotensive and inotropic effects, improves glucose utilization, which emphasizes its importance in the pathogenesis as essential hypertension (EH) and type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the blood levels of apelin in patients with EH in combination with T2DM.Description of methods/design: The examination involved 19 patients with EH grades 2–3 with T2DM (eigh...

ea0035p181 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Adherence to treatment in hypertension and diabetes

Rusalenko Maryia , Korotaev Aleks , Shilova Nataliya , Mokhort Tatyana , Rozhko Aleksandr

Objective: To study the effectiveness of therapy and the role of adherence to treatment in patients with DM and AH.Methods: A 75 patients studied with Moriski-Green test. Psycho-correctional work has been carried out with 37 people (Group 1) in order to increase motivation for treatment, and the work has not been carried out with 38 people (Group 2). The treatment effect has been evaluated after 3 months according the results of sBP and dBP dynamics and ...

ea0035p182 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Evaluation of lipid levels in familial hypercholesterolemia in a lipid unit

Gonzalez-Molero Inmaculada , Vallejo Rosario , Omiste Antonio , Tinahones Francisco

Objective: To determine the degree of control of hypercholesterolemia in a specific lipid unit.Material and Methods: Retrospective study of patients followed in our unit over the past 16 years diagnosed with heterozygous familial hypercholesterolemia (HFH) or familial combined hyperlipidemia (FCH). Control criteria according to the following recommendations were compared: International Panel (2003), Nice (2008), NLA (2011), ESC / ESA 2011, Consensus ADA ...

ea0035p183 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Association between serum thyrotropin levels and insulin resistance in euthyroid patients

Sahin Murat , Korkut Ismail , Oguz Ayten , Yavuz Yasemin Coskun , Gisi Kadir , Gul Kamile

Aim: Thyroid hormones act both insulin agonistic and antagonistic in different organs. Studies that evaluate the relationship between insulin resistance and hypo-hyperthyroidism have conflicting results, even euthyroid status was shown to change insulin sensitivity. In this study, our aim is to investigate the association between TSH, free T4, free T3 levels and insulin resistance in euthyroid patients.Method: Euthyroid 57 males, 47...

ea0035p184 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Features of patients with familial hypercholesterolemia treated in a specific lipid unit

Gonzalez-Molero Inmaculada , Vallejo Rosario , Omiste Antonio , Olveira Gabriel , Tinahones Francisco

Objective: To determine the characteristics of patients with familiar hypercholesterolemia studied in a specific unit of lipids.Material and methods: A descriptive study of patients followed in our unit over the last 16 years diagnosed with heterozygous familial hypercholesterolemia (HFH) or familial combined hyperlipidemia (FCH).Results: Data from 111 patients were analyzed: 66 with HFH and 45 with FCH.Featu...

ea0035p185 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Bariatric surgery effects in lipids levels

Gonzalez-Molero Inmaculada , Gonzalo-Marin Montserrat , Arnes Juan Antonio Garcia , Maldonado Cristina , Valdes Sergio , Tinahones Francisco

Aim: To analyze the influence of bariatric surgery over serum lipids in patients with morbid obesity after 1 year of surgery.Methods: Retrospective study of 88 patients before and after 1 year of bariatric surgery (65 by pass and 23 sleeve). We collected data about age, sex, other diseases, anthropometric measures and biochemical parameters: glucose, uric acid, total cholesterol (TC), HDL-C, LDL-C, triglycerides (TG), VLDL and non-HDL-C, homocistein and ...

ea0035p186 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Prevalence of hyperandrogenism and polycystic ovary syndrome in female to male transsexuals

Becerra-Fernandez Antonio , Menacho-Roman Miriam , Perez-Lopez Gilberto , Lucio-Perez Maria Jesus , Asenjo-Araque Nuria , Rodriguez-Molina Jose Miguel , Villar-Vicente Maria Rosa

Prevalence of hyperandrogenism (HA) and polycystic ovary syndrome (PCOS) in female to male transsexuals (FMT) is controversial. To known the prevalence of hyperandrogenism and PCOS in FMT, and their relation with insulin resistance (IR) and other cardiovascular risk factors (CVRF), we studied 77 Spanish consecutive FMT cases, the first ones who appeared in our Gender Unit between May 2007 and Dec 2008, aged 18–43 years. The subjects had never received hormonal treatment o...

ea0035p187 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Metabolic outcomes in childhood cancer survivors

Tselovalnikova Tatiana , Pavlova Maria , Zilov Alexey , Mazerkina Nadezhda , Zheludkova Olga

Aim: The aim of this study was to evaluate metabolic abnormalities in young adults getting treatments of acute lymphoblastic leukemia (ALL) and brain tumors (BT) in their childhood.Methods: We examined 50 patients in two groups. The group-1: 18 ALL-survivors (nine women and nine men). All of them received cranial irradiation in dose up to 18 Gy and chemotherapy. In group-2: 32 BT-survivors (14 women and 18 men) were included. All patients received cranio...

ea0035p188 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

The associations between parathyroid hormone level and coronary artery diseases in subjects without significant renal dysfunction

Kim Kyoung Min , Choi Sung Hee , Shin Chan Soo , Jang Hak Chul , Lim Soo

Introduction: Elevated parathyroid hormone (PTH) levels are associated with increased cardiovascular diseases (CVD) in the patients with impaired kidney function. We aimed to investigate whether PTH levels are associated with CVD in persons without significant renal diseases.Methods: This is a cross-sectional study and we included 1951 Korean subjects aged ≥30 years (men 46.6%), who underwent 64-slice multidetector-row cardiac computed tomography (...

ea0035p189 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Serum cholesterol concentration and prevalence, awareness, treatment, and control of high LDL cholesterol in the Korea National Health and Nutrition Examination Surveys 2008–2010

Lee Yong-ho , Lee Byung-Wan , Kang Eun Seok , Lee Hyun Chul , Baik Sei Hyun , Kim Dong-Sun , Cha Bong Soo

Introduction: The mortality rate from cardiovascular disease (CVD) among young adults has declined less than that in the older population, raising concerns about the increasing prevalence of obesity-related conditions including hypercholesterolemia in the younger population. We investigated the age-standardized mean levels of serum cholesterols and the prevalence, awareness, treatment and control rates of hyper-LDL-cholesterolemia based on age.Methods: N...

ea0035p190 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Anomalies of the lipid balance in hypothyroidism: comparative study by sex

Youcef Raddhia Si , Saraoui Fatima , Youcef Hafsa Si , Fedala Nora Soumaya , Chentli Farida

Introduction: The thyroid hypofunction is at origin of lipid metabolism disorder that enhances cardiovascular risk and increases morbidity and mortality.Objective: Search for lipid disorders in hypothyroidism comparing the results between the two sexes.Population and Method: Retrospective study of 72 patients (54 F and 18 H), mean age of 55.63 years (53.66 F and 61.5 H) hospitalized between 1996 and 2012 for primary hypothyroidism....

ea0035p191 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

The pericarditis in the hypothyroidism

Youcef Radhia Si , Saraoui Fatima , Youcef Hafsa Si , Fedala Nora Soumaya , Chentli Farida

Introduction: Pericarditis includes all inflammatory affections of the serous covering of the heart. The clinical expression and etiology of these disorders are highly variable. Of these, hypothyroidism is an important issue to recognize.Objective: Find the frequency of pericardial effusion in primary hypothyroidism and appreciate its clinical and evolutionary characteristics.Population and method: A retrospective study in 72 patie...

ea0035p192 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Vascular calcification: differences between atherosclerotic changes and media sclerosis? A pilot study

Schweighofer Natascha , Aigelsreiter Ariane , Graf-Rechberger Martina , Hacker Nicole , Iberer Florian , Kniepeiss Daniela , Wagner Doris , Stiegler Philipp , Gutschi Jurgen , Trummer Olivia , Sinner Frank , Pieber Thomas , Muller Helmut , Obermayer-Pietsch Barbara

Background: Calcification occurs physiologically in bone and pathophysiologically in the vasculature. Cardiovascular diseases are among the most common causes of death within patients with chronic kidney disease and crucial for kidney transplantation (RTX) outcomes.Methods and aim: We investigated the pattern and the onset of expression of regulators of calcification (RC) in the arteria iliaca externa in 26 donors (D) and 25 recipients (R) of RTX to iden...

ea0035p193 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Apelin as a marker of an insulin resistance in patients with essential hypertension

Demydenko Ganna , Kovalyova Olga

Aim of investigation was to estimate a serum level of apelin in patients (pts) with essential hypertension and insulin resistance.Methods: 94 patients with EH were examined. Carbohydrate and lipid metabolisms were investigated. Apelin’s blood levels were estimated by ELISA ‘Phoenix’, USA. Insuline resistance (IR) criteria was insulin level more than 12.2 mkU/ml. Data is present as median (Q25 and Q75). FINDRISK questionnaire was used to es...

ea0035p194 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Insulin dynamics and its associated signalling pathways in equids predisposed to laminitis

Timpson Amy , Elliott Jonathan , Harris Patricia , Mestre Amanda de , Menzies-Gow Nicola

Laminitis, an inflammatory condition of the sensitive and specialised architecture (the laminae) in the equine hoof, can be induced by over-ingestion of non-structural carbohydrates (NSC) from spring/summer pasture. Some equids that are predisposed to laminitis appear to share characteristics described in human patients with metabolic syndrome, such as vascular dysfunction, obesity, development of an inflammatory profile and insulin resistance. We investigated whether adipose ...

ea0035p195 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Laminitis: finding the key to predisposition of the metabolic disorder affecting the hoof in equids

Timpson Amy , Elliott Jonathan , Harris Patricia , Cheng Zhangrui , Rainbow Lucille , Mestre Amanda de , Menzies-Gow Nicola

Laminitis, an inflammatory condition of the sensitive and specialised architecture (the laminae) in the equine hoof, can be induced by over-ingestion of non-structural carbohydrates (NSC) from spring/summer pasture. Some equids that are predisposed to laminitis appear to share characteristics described in human patients with metabolic syndrome. We investigated if adipose tissue from laminitis prone equids (LP) functions differently from non-laminitis prone equids (NL), by exam...

ea0035p196 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Fetuin-A as a marker of cardiovascular risk in patients with type 2 diabetes

Dabrowska Anna , Tarach Jerzy , Wojtysiak-Duma Beata , Malecha-Jedraszek Arleta , Torun-Jurkowska Anna , Kudlicki Janusz , Donica Helena

Introduction: It is known that type 2 diabetes increases the risk of cardiovascular disease. Fetuin-A is a multifunctional serum glycoprotein and its role in the pathogenesis of type 2 diabetes, atherosclerosis and cardiovascular disease is still discussed.Material and methods: The study was conducted in 36 patients (12 F and 24 M) with type 2 diabetes mellitus (DM2) and acute coronary syndrome (ACS), aged mean 70.22±7.62. The group was divided into...

ea0035p197 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Osteoprotegerin as a marker of myocardial damage in patients with type 2 diabetes and acute coronary syndrome

Dabrowska Anna , Tarach Jerzy , Malecha-Jedraszek Arleta , Wojtysiak-Duma Beata , Torun-Jurkowska Anna , Kudlicki Janusz , Donica Helena

Introduction: It’s known that type 2 diabetes increases the risk of cardiovascular disease. Silent myocardial ischemia occurs frequently in diabetics and may result in more severe coronary artery disease. Osteoprotegerin (OPG) is a glycoprotein secreted mainly by osteoblasts but it’s also produced by heart muscle. Its role in the pathogenesis of type 2 diabetes, atherosclerosis and future cardiovascular events is still discussed.Material and me...

ea0035p198 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Epigenetic control of renin–angiotensin–aldosterone system in hypertrophic heart

Takeda Yoshiyu , Wang Fen , Demura Masashi , Yoneda Takashi , Karashima Shigehiro , Cheng Yuan , Kometani Mitsuhiro , Ohe Masashi

The activation of local renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the overall pathophysiology of the cardiovascular diseases. We have reported increased mRNA levels of angiotensinogen, angiotensin converting enzyme (ACE) and CYP11B2 (aldosterone synthase gene) in the heart of salt-sensitive hypertensive rats complicated with cardiac hypertrophy. However, the mechanism of control of gene expression of each component of RAAS gene in the heart is unknown...

ea0035p199 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Occurrence of hipothyreosis in patients with metabolic syndrome

Gierach Marcin , Junik Roman

Metabolic syndrome is an important social problem concerning a growing number of people. In different countries across Europe, its incidence is estimated at 17.4–28%. The metabolic syndrome is a constellation of risk factors for cardiovascular diseases. Hipothyreosis can additionally influence on lipid and carbohydrate disorders.The described study was a prospective, two-centre (A. Jurasz University Hospital No. 1 in Bydgoszcz, District Hospital in ...

ea0035p200 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Flexibility of ectopic lipids in physically active, healthy individuals

Bucher Julie , Krusi Marion , Kreis Roland , Zuger Thomas , Ith Michael , Stettler Christoph , Boesch Chris

Introduction: Ectopic lipids are fuel stores in non-adipose tissues (i.e. skeletal muscle (IMCL), liver (IHCL), heart (ICCL)). An aerobic-exercise bout leads to a decrease in IMCL (‘working tissues’), whereas it is not established whether a single but of exercise influences IHCL or ICCL.Increased IMCL and IHCL have been related to impaired insulin action in skeletal muscle and liver. It is hypothesized that fat availability (subcutaneous and vi...

ea0035p201 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Low testosterone syndrome protects from major adverse cardiovascular events in subjects at high cardiovascular burden

Corona Giovanni , Ratrelli Giulia , Maseroli Elisa , Forti Gianni , Maggi Mario

Introduction: The role of testosterone in cardiovascular (CV) health of men is controversial. Several data suggest that hypogonadism is associated with CV mortality but not morbidity. However, recent evidence shows that hypogonadal subjects treated with testosterone replacement therapy have a higher incidence of major adverse CV events (MACE). The aim of this study is to analyse whether the gonadal status might predict MACE incidence according to the previous history of MACE, ...

ea0035p202 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Serum homocysteine levels are decreased in levothyroxine-treated women with autoimmune thyroiditis

Owecki Maciej , Dorszewska Jolanta , Sawicka-Gutaj Nadia , Oczkowska Anna , Owecki Michal K , Michalak Michal , Fischbach Jakub , Kozubski Wojciech , Ruchala Marek

Introduction: Some studies suggest that thyroid autoimmunity might be associated with increased cardiovascular-risk. However, the exact pathophysiology of this relationship has not yet been fully understood. In this study we aimed to analyze the influence of the levothyroixine (L-T4) replacement therapy and of anti-thyroperoxidase antibodies (TPOAbs) on homocysteine (Hcy) levels in patients with thyroid autoimmune disease.Method...

ea0035p203 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

ARR screening using IDS-iSYS aldosterone and direct renin: effects of medication in essential and renovascular hypertension, Cushing's syndrome and primary aldosteronism

Sustarsic Riia , Lonati Chiara , Manolopoulou Jenny , Reincke Martin , Bidlingmaier Martin , Morganti Alberto

Background: Identifying hypertensive patients with primary aldosteronism (PA) using the aldosterone to renin ratio (ARR) is crucial for optimizing their treatment. Various medications used to treat hypertension are known to alter levels of aldosterone and renin, thus affecting the ARR. As withdrawing all medication before screening is often unrealistic, we aimed to determine the degree of interference of some commonly used agents on the ARR using assays on the automated IDS-iS...

ea0035p204 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

eNOS, p22 phox, CETP and ERα gene polymorphisms related to metabolic–endocrine parameters in postmenopausal women with metabolic syndrome: a population based study

Ianas Olga , Manda Dana , Vladoiu Susana , Popa Oana , Rosca Roxana , Oros Sabina , Covic Marcela , Heltianu Constantina , Sima Anca , Savu Lorand , Giurcaneanu Mihaela

Objective: We previously found an association between eNOS(G894T) polymorphism and components of metabolic syndrome (MetS); thus, we investigated the metabolic–endocrine changes in postmenopausal women with incipient MetS and the interaction with the polymorphisms of eNOS-G894T, p22phox-930 A/G, CETP TaqIB and ESR1 (PvuII and XbaI) genes.Methods: postmenopausal women aged between 60 and 80 years from a population-based study were classified into the...

ea0035p205 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Identification of 4 statin benefit groups according to NHLBI ATP IV criteria among Venezuelan women: EEM–lipid study

Guanipa-Sierra Wilfredo , Sanchez-Zambrano Martha , Feijoo-Iglesias Josefina , Pizzi-La Veglia Rita , Marquez Ingrid , Sanchez Felix , Lugo Adalberto , Castillo Eglee , Diaz Luis , Flores Auris

The 2013 guideline (NHLBI ATP IV) on the treatment of blood cholesterol in adults was recently published. It focuses on identification of 4 Statin Benefit Groups (4SBG), in which the potential for Atherosclerotic Cardiovascular Disease (ASCVD) risk reduction benefit clearly exceeds the potential for adverse effects.Objective: To estimate the prevalence of 4SBG among Venezuelan women and to determine its association with hypertension, BMI, waist circumfer...

ea0035p206 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Alterations in ambulatory blood pressure monitoring are frequent and associated to cardiovascular risk factors in patients with type 1 diabetes

Vilchez-Lopez Francisco Javier , Mateo-Gavira Isabel , Laureano Florentino Carral-San , Garcia-Palacios Maria Victoria , Ortego-Rojo Jose , Aguilar-Diosdado Manuel

Objectives: To evaluate the prevalence of blood pressure alterations by ABPM and its association with clinical factors in normotensive and normoalbuminuric patients with type 1 diabetes (TDM1).Methods: Cross-sectional study including normotensive and normoalbuminuric patients with TDM1. Altered ABPM was considered when: i) Mean systolic pressure (sBP) was ≥130 mmHg in the 24 h and daytime periods and ≥120 mmHg in the night-time period and/or ...

ea0035p207 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Flaccid penile acceleration as a marker of cardiovascular risk in men without classical risk factors

Rastrelli Giulia , Corona Giovanni , Lotti Francesco , Aversa Antonio , Bartolini Marco , Mancini Mario , Mannucci Edoardo , Maggi Mario

Introduction: Conventional cardiovascular (CV) risk factors identify only half of subjects with incident major adverse CV events (MACE). Hence new markers are needed in high CV risk subjects, as those with erectile dysfunction (ED). A role for dynamic peak systolic velocity (D-PSV) at penile color Doppler ultrasound (PCDU) has been suggested, but it is operator-dependent and time-consuming. Flaccid penile acceleration (FPA) is a PCDU parameter that reflects PSV, the systolic r...

ea0035p208 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Total and HDL-cholesterol are lower in lean PCOS women

Milewicz Tomasz , Kawula Agnieszka , Guzik Justyna , Krzyczkowska-Sendrakowska Magdalena , Krzysiek Jozef

Aim: To assess lipid levels in patients with PCOS and normal body weight.Materials and methods: 139 patients admitted to the Gynaecologic Endocrinology Clinic of the Jagiellonian University’s Collegium Medicum agreed to take part in this research, and PCOS, according to the Rotterdam criteria, was found in 96 of them. The control group consisted of 43 patients with FAI <5. All of the 96 patients had a normal (BMI <25) body weight. This index...

ea0035p209 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2014

LDL cholesterol is higher in overweight and obese PCOS women

Milewicz Tomasz , Guzik Justyna , Kawula Agnieszka , Krzyczkowska-Sendrakowska Magdalena , Krzysiek Jozef

Aim: To assess lipid levels in patients with PCOS and BMI >25.Materials and methods: 102 patients admitted to the Gynaecologic Endocrinology Clinic of the Jagiellonian University’s Collegium Medicum agreed to take part in this research, and PCOS, according to the Rotterdam criteria, was found in 87 of them. The control group consisted of 15 patients with FAI <5. All of the 87 patients had BMI >25. This index, as well as blood samples, we...