Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2014) 35 P1048 | DOI: 10.1530/endoabs.35.P1048

1School of Medicine Section of Endocrinology and Metabolism, Marmara University, Istanbul, Turkey; 2Malatya State Hospital, Malatya, Turkey; 3Ondokuz Mayis University, Samsun, Turkey; 4School of Medicine, Abant Izzet Baysal University, Duzce, Turkey; 5Medical School, Celal Bayar University, Manisa, Turkey; 6Medical School, Inonu University, Malatya, Turkey; 7Giresun State Hospital, Giresun, Turkey; 8Medical School, Namik Kemal University, Tekirdag, Turkey; 9School of Medicine, Ege University, Izmir, Turkey; 10Fatih Sultan Mehmet Hospital, Istanbul, Turkey; 11Uskudar State Hospital, Istanbul, Turkey; 12Kilis State Hospital, Gaziantep, Turkey.


Non adherence to medication schedules by patients with chronic illnesses has long been recognized as a problem. The aim of this study is to evaluate levothyroxine (L-T4) compliance, daily dosage and TSH levels under treatment in primary hypothyroid patients.

We included 1636 primary hypothyroid patients over 1 year under L-T4 (F/M: 1469/167, 46±13 years of age) included from 11 tertiary health care centres around Turkey. A survey covers on disease duration, daily dosage, adherence to L-T4 recommendations were performed.

Duration of the L-T4 treatment was 5.9±6.7 years, L-T4 dosage was 96.6 μg/day and 1.3 μg/kg per day, TSH level was 4.8 mIU/l 32.3% of patients were not compliant to the treatment. Compliance rates differs between the centres with a maximum 84% and minimum 55%.

Noncompliant patients have higher TSH (6.9±16 vs 3.8±0.9 mIU/l, P=0.01) and shorter duration of disease (5.8±6.9 vs 6.0±6.5 years, P<0.05) compared to compliant patients. There was no difference of, dosage of L-T4 between compliant and non-compliant patients.

Our results suggest that non-compliance of L-T4 treatment is associated with subclinical hypothyroidism in our study group. Approximately 67.7% of patients follow treatment recommendations but compliance rates differs between the centre’s. The physician–patient relationship seems to have key role in adherence to levothyroxine regimen.

Article tools

My recent searches

No recent searches.