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Endocrine Abstracts (2014) 35 P267 | DOI: 10.1530/endoabs.35.P267

Pirogov Medical Center, Saint-Petersburg, Russia.


Background: Fine needle aspiration biopsy is generally acknowledged as a «gold standard» for diagnostics of thyroid malignancies. However, data on FNAB vary considerably in publications from different centers. In this study we have analyzed the results of more than 40 000 FNAB of thyroid nodules performed in North-West Regional Endocrine Center during 2010–2012 years.

Subjects and methods: Indication for FNAB was a thyroid nodule of ≥1 cm, and a nodule <1 cm with clinical and ultrasound signs suspicious for malignancy. In case of multinodular goiter each nodule was examined separately. Female-male ratio was 10:1. Mean age for women was 56.0±13.7 years, for men – 54.7±14.8 years.

Results: Cytological results were as follows according to the Bethesda system: noninformative – 8%, benign nodules – 81.9% (colloid nodules 71.6%, Hashimoto’s thyroditis – 10.2%, subacute thyroditis and others – 0.02%), follicular lesion – 7.2% (follicular neoplasm – 7.1%, follicular lesion of inderterminate significance – 0.1%), suspicious for malignancy – 0.02%; malignant tumours – 3%, among the latter 93.0% were papillary carcinomas.

Conclusion: The presented results based on analysis of more than 40 000 FNAB confirm that this method is highly informative in detection of thyroid malignancies. Application of FNAB significantly increases number of patients submitted to surgery due to a malignant tumour, and decreases quantity of diagnostic operations. Only 12.5% operations in 2004 were performed in our clinics in patients with malignancies but in 2012 its percentage increases up to 53%.

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