Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2014) 35 P760 | DOI: 10.1530/endoabs.35.P760

ECE2014 Poster Presentations Obesity (53 abstracts)

Worsening of cardiovascular risk with increasing number of components of metabolic syndrome in obese non-diabetic individuals

Bruce Wolffenbuttel , Sandra Slagter , André Van Beek , Helen Lutgers , Jana Van Vliet-Ostaptchouk & Melanie Van der Klauw


University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.


Introduction: The metabolic syndrome (MetS) is a strong predictor of cardiovascular risk. It is influenced by environmental factors, and its prevalence is high in subjects with obesity.

Design: We assessed differences in glucose- and lipid parameters, and hsCRP and microalbuminuria (MA) in obese subjects with and without metabolic syndrome (MetS) in LifeLines, a population-based study. Included were subjects 18–80 years, with BMI>30 kg/m2. We excluded subjects known to diabetes, with fasting blood glucose (FBG) >7.0 mmol/l, or using statins. MetS was defined according to revised NCEP ATP III criteria.

Results: A total of 9297 individuals (61% women) participated. Their mean age was 46±12 years, median BMI 32.3 kg/m2 (IQR 30.9–34.7). In addition to waist circumference, elevated blood pressure was the most prevalent component (Co) of MetS (60%), while elevated FBG was only present in 21%. There was a gradual and highly significant (P<0.001) increase of FBG, HbA1c and serum total and LDL-cholesterol with increasing number of components of MetS (table). We also observed an increase of MA, a marker of endothelial function and cardiovascular risk, but not of hsCRP.

No MetS Co1234+5P
n 1809340424261658
Age-yrs43±1046±1247±1248±11<0.001
FBG mmol/l4.9±0.45.0±0.45.3±0.55.6±0.6<0.001
HbA1c-%5.5±0.35.6±0.35.7±0.35.8±0.4<0.001
Tchol mmol/l5.0±0.95.2±1.05.3±1.05.5±1.0<0.001
HsCRP mg/l2.6 (1.2–5.6)2.8 (1.3–5.7)2.9 (1.4–6.2)3.0 (1.5–5.6)0.051
MA mg/l1.8 (1.1–3.1)2.1 (1.2–3.9)2.4 (1.3–5.0)2.8 (1.5–5.6)<0.001
Data as mean±S.D. or median (IQR)

Conclusion: Both glucose- and lipid-related parameters and albuminuria worsen with increasing number of components of MetS, reflecting the increase of cardiovascular risk associated with this syndrome.

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