Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2014) 35 P80 | DOI: 10.1530/endoabs.35.P80

ECE2014 Poster Presentations Bone and Osteoporosis (36 abstracts)

1,25-dihydroxyvitamin D3 decreases the proinflammatory interleukin 17 serum levels

Ildikó Molnár 1 , llona Bohaty 2 & Éva Somogyiné-Vári 3


1Immunoendocrinology and Osteoporosis Centre, EndoMed, Debrecen, Hungary; 2Regional Centre of Hungarian National Blood Transfusion Service, Debrecen, Hungary; 3Immunoendocrinology and Osteoporosis Centre, EndoMed, Debrecen, Hungary.


Proinlfammatory cytokines, such as interleukin 17 (IL17) are involved in different inflammatory events causing cardiovascular diseases, osteoporosis and/or infertility. 1,25-dihydroxyvitamin D3 (vitamin D3) plays an immunomodulatory role and therefore, vitamin D3 deficiency can propagate the development of autoimmune diseases, infections and cancers.

The effect of vitamin D3 on proinflammatory cytokine levels, such as on IL17, IL6 and monocyte chemoattractant protein-1 (MCP-1) was investigated in 54 women (mean age 60 years). IL17, IL6 and MCP-1 and vitamin D3 serum levels were measured by ELISA and chemiluminescence method respectively.

Forty-three women showed vitamin D3 deficiency (27.45±10.81 nmol/l) and 11 women had only sufficient 68.95±18.44 nmol/l) vitamin D3 levels. Women with vitamin D3 deficiency demonstrated higher IL17 (12.5±2.83 vs 11±1.9 ng/ml, P<0.49), IL6 (26.19±12.26 vs 22.68±13.52 ng/ml, NS) and MCP-1 (16.92±2.45 vs 16.18±1.23 ng/ml, NS) levels compared with those, which women had sufficient vitamin D3 levels. An inversely correlation was found between IL17 and vitamin D3 levels (P<0.026, r=0.3033).

The results highlight the importance of sufficient vitamin D3 concentration in the decrease of IL17 levels.

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