Searchable abstracts of presentations at key conferences in endocrinology
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42nd Meeting of the British Society for Paediatric Endocrinology and Diabetes

Oral Communications

Oral Communications 3

ea0036oc3.1 | Oral Communications 3 | BSPED2014

The Scottish audit of atypical genitalia: first year results

Jayasena Arundathi , Rodie Martina , Ahmed Faisal

Introduction: The early management of atypical genitalia has been highlighted as being of critical importance by the UK-DSD guidance in 2011.Objectives: To estimate the incidence of atypical genitalia requiring early specialist input in neonates and its clinical presentation and management.Method: Prospective audit through the Scottish DSD network and the Scottish Paediatric Endocrine Group, between June 2013 and June 2014. Monthly...

ea0036oc3.2 | Oral Communications 3 | BSPED2014

Vertebral fracture assessment in a paediatric population using dual-energy X-ray absorptiometry

Kyriakou Andreas , Shepherd Sheila , Lucaccioni Laura , Shaikh M Guftar , Mason Avril , Ahmed S Faisal

Background: Vertebral Fractures (VF) are recognized as an important aspect of bone health in children and adolescents. The clinical utility of vertebral fracture assessment (VFA) using dual-energy X-ray absorptiometry (DXA) has not been evaluated in the paediatric population.Method: VFA was performed independently by two non-radiologist observers, in 165 patients (77M/88F) as part of their investigation for low bone mineral density. Lateral thoracolumbar...

ea0036oc3.3 | Oral Communications 3 | BSPED2014

An analysis of meta-data from three UK centres on the sequelae of paediatric craniopharyngiomas over four decades

Tan Timothy Shao Ern , Gopal-Kothandapani Jaya Sujatha , Ikazoboh Esieza Clare , Skae Mars , De Vile Catherine , Ehtisham Sarah , Kamaly-Asl Ian , Mallucci Conor , Thorpe Nicky , Pizer Barry , Didi Mohammed , Blair Jo , Patel Leena , Spoudeas Helen , Clayton Peter

Background: The optimal management of paediatric craniopharyngiomas has been debated for years. Radical surgery aimed at complete resection (CR) was the approach for several decades, with higher reported rates of tumour control compared with incomplete resection (IR). The shift towards conservative surgery with adjuvant radiotherapy (DXT), aimed at reducing post-operative morbidities, especially hypothalamic and visual, has not been systematically studied.<p class="abstext...

ea0036oc3.4 | Oral Communications 3 | BSPED2014

Standard population screening for diabetes mellitus has low sensitivity in identifying diabetes in adult survivors of childhood bone marrow transplantation with total body irradiation

Wei Christina , Unsworth Rebecca , Davis Nikki , Bradley Karin , Cox Rachel , Stevens Michael , Crowne Elizabeth

Background: Adult survivors of childhood leukaemia treated with bone marrow transplantation and total body irradiation (BMT/TBI) have an increased risk of diabetes mellitus (DM) disproportionate to their level of adiposity or other recognised risk factors. Post prandial hyperglycaemia due to reduced β-cell reserve after irradiation will be missed by fasting glucose (FG) levels. However, the UK National Institute of Clinical Excellence (NICE) screening guidelines recommend...

ea0036oc3.5 | Oral Communications 3 | BSPED2014

Statistical prediction of HRpQCT microstructural trabecular parameters using 1.5T skeletal MRI

Dimitri Paul , Lekadir Karim , Whitby Elspeth , Armitage Paul , Hoogendoorn Corne , Franji Alejandro

Background: High resolution peripheral quantitative computed tomography (HRpQCT) can accurately determine three-dimensional in-vivo skeletal microstructure. However, HRpQCT is limited to the ultradistal radius and tibia (9 mm) imaging. MRI may be an alternative approach to cortical and trabecular bone analysis; to date there is limited information regarding the accurate quantification of trabecular bone.Method: Ninety-three 13–16 years-old ...

ea0036oc3.6 | Oral Communications 3 | BSPED2014

A novel non-invasive short Synacthen test

Elder Charlotte , Johnson Trevor , Loxley Martin , Wales Jerry , Wright Neil

Introduction: The short Synacthen test (SST) is a popular diagnostic investigation for adrenal insufficiency (AI). Cannulation and blood sampling are required making it invasive, time-consuming and resource-intensive. Salivary cortisol is a well-established alternative to serum sampling. We have developed a non-invasive alternative to the 1 μg SST, using a novel formulation of Synacthen (with a nasal drug enhancer, chitosan) given nasally and utilising saliva to measure t...

ea0036oc3.7 | Oral Communications 3 | BSPED2014

Patterns of gene expression in pre-pubertal children are associated with the severity of their GH deficiency

Stevens Adam , De Leonibus Chiara , Chatelain Pierre , Murray Philip , Clayton Peter

Background: GH deficiency (GHD) has a spectrum of severity as characterised by GH stimulation tests; the cut-off level for GHD has been a long standing contentious issue. An independent biological correlate of severity would be valuable.Objectives: To identify patterns of gene expression (GE) that correlate with severity in GHD.Methods: Pre-pubertal children with GHD (n=72) were enrolled from the PREDICT study (NCT00256126...

ea0036oc3.8 | Oral Communications 3 | BSPED2014

Trends in off-label prescription of GH: results from the National GH Audit

Saraff Vrinda , Shepherd Sheila , Shaw Nick

Introduction: National Institute of Health and Care Excellence (NICE) has provided guidance for the use of human recombinant GH in the treatment of growth failure in children. An ongoing National GH Audit was established in 2013 by BSPED to maintain a central database and gather information regarding trends in prescribing and facilitate future long-term follow up. This part of the audit looked at the trends of off label prescribing of GH.Method: Data wer...

ea0036oc3.9 | Oral Communications 3 | BSPED2014

Physiological dose reverse rhythm testosterone treatment abolishes the development of permanent gynaecomastia in adolescents with 47,XXY Klinefelter syndrome

Butler Gary

Introduction: Gynaecomastia (GM) is common in boys with Klinefelter syndrome (KS) during adolescence. It develops due to the relatively higher diurnal oestradiol–testosterone ratio in early to mid puberty. The physiological mid-late pubertal rise in testosterone causes the GM to disappear in chromosomally normal boys, but it persists in boys with KS if this rise in testosterone is blunted.Aim: As a previous longitudinal RCT of testosterone in boys w...