Endocrine Abstracts

Introduction: Outcomes of the National Paediatric Diabetes Audit have shown that patients of Black ethnic origin have poorer glycaemic control. Additional professional contacts mandated by the Best Practice Tariff aim to improve glycaemic control in paediatric patients with diabetes mellitus, but do not allow for differing needs.Aim: To evaluate whether additional professional support for paediatric diabetic patients are targeted at those with worst glyc...

Background: Oxidative stress has been implicated in the development and progression of complications in type 1 diabetes (T1DM). Vitamin E (α-tocopherol) undergoes β-oxidation of its chomanol ring and the resulting metabolite α-TLHQ has been proposed as a potential biomarker of oxidative stress. HbA1c relates in T1DM to microvascular complications predominantly although the end-points are late in disease development. The oxidative stress process may act independe...

Objectives: Glycaemic targets set by diabetes teams appear to have an impact on glycaemic control. Our objective was to identify if there is consensus between and within teams in our network on glycaemic targets and whether this correlates with HbA1c outcomes.Methods: An online survey was sent to all network members requesting an independent response on the diabetes self-management advice given to families. Three patient groups were considered: children ...

Background: Hyperosmolar hyperglycaemic state (HHS) is a life-threatening condition that can be the initial presentation of type 2 diabetes mellitus. This condition is characterized by severe hyperglycaemia, a high serum osmolality and dehydration without accumulation of ketoacids. We report two patients who presented with mixed features of HHS and DKA.Case 1: An 11-year-old Afro-Caribbean boy with severe developmental delay presented with a 4-week histo...

Introduction: Type 1 diabetes affects a large number of children and adolescents, and its incidence is on the rise worldwide. The most devastating and important consequence of diabetes is its role in the development of long-term microvascular complications. This study aimed to study the role of the non-invasive vibration perception threshold (VPT) test in detecting subclinical peripheral neuropathy, and its correlation with metabolic control and duration of disease in British ...