Endocrine Abstracts

Background: Celiac disease is frequently associated with type 1 diabetes mellitus, but is usually ill-defined and not usually suspected until the disease become advance.

Aim: To study the prevalence, clinical profile and glycemic variability and the effect of gluten free diet on growth and diabetic control in celiac type 1 diabetes patients in a tertiary care referral centre in north India.

Materials and method: Total of 256 patients were screened (149 males and 107 females) during the study period of 2 years, patients were evaluated for the clinical signs, biochemical investigations and family history of celiac disease in tertiary care health center in western U.P.

Results: Twenty-four (9.37%) patients were diagnosed to have celiac disease; the mean age at diagnosis of diabetes was 9.34±7.3 years. Only 1/24 patients with celiac disease had been diagnosed before detection of diabetes mellitus. The common manifestations were normocytic normochromic anemia (66.6%) followed by diarrhoea (62.5%), abdominal pain/bloating sensation (58.3%), and short stature (58.3%). Weight SDS increased from –0.12±1.3 at the start of gluten free diet to 0.8±0.9 after 12 months later (P<0.05). Height SDS increased from −2.46±1.1 at the start of gluten free diet to −2.14±0.9 after 12 months later (P=0.087). Bone age SDS increased from 9.2±6.3 at the start of gluten free diet to 10.3±6.7 after 12 months later. Height velocity increased from 4.7±0.7 cm/year in the year before treatment to 5.1±1.2 during treatment (P=0.05). The increased in hemoglobin, serum calcium, and serum iron is statistically significant (P<0.05).

Conculsion: Celiac disease was found to be significantly associated with type 1 diabetes, timely identification of these disorder are of paramount important for better glycemic control and to reduced the morbidity and mortality associated with the conditions.