Endocrine Abstracts

Background: Diabetes and osteoporosis are both frequent conditions, a link may thus put a substantial number of patients at risk of fragility fractures and the consequences of these such as pain, disability, and increased mortality. Skeletal fragility and osteoporosis may represent a hitherto overlooked complication of diabetes in line with say diabetic eye disease, diabetic nephropathy etc.Findings: An increased risk of fractures has been observed in bo...

Both type 1 and 2 diabetes are associated with an increased fracture risk. Whereas in type 1 bone fragility is mostly explained by a lower peak bone mass and low bone turnover state, which is a common feature of several chronic and/or inflammatory diseases starting during growth, in type 2 diabetes there is not necessarily low bone mass, rather a higher aBMD related to overweight/obesity in these subjects. To explain the increased propensity to fractures in this case, a higher...

Given the increasingly accepted increase in fracture risk that occurs in patients with type 2 diabetes, a number of strategies need to be considered reflecting the multiple factors underlying the fracture risk. These comprise measures to improve falls risk, the avoidance of treatments that may be detrimental to skeletal health and the use of treatments to maintain or improve bone strength.Older people with diabetes are at high risk of falls, recurrent fa...