Endocrine Abstracts

Aggressive pituitary tumours, characterized by tumor recurrence and continued progression despite repeated treatments and pituitary carcinomas respond poorly to conventional therapies. The first reports describing the successful use of temozolomide (TMZ), an orally administered alkylating agent used to treat malignant gliomas, in the management of pituitary carcinomas were published in 2006. Following these single case reports small series of patients have detailed the success...

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