Searchable abstracts of presentations at key conferences in endocrinology
ea0037mte2 | (1) | ECE2015
Management of prolactinoma
Prolactinomas are the most common pituitary tumours with a prevalence varying from 0.3 to 0.5/1000 in the general population. This tumor has a large female predominance and a median age at diagnosis of 30 years. Prolactinomas in men are characterized by a larger size and a higher frequency of compressive symptoms, invasiveness, and resistance to therapy. Although the diagnosis of prolactinoma is often straightforward and the treatment strategy has been well defined in recent g...
ea0037mte4 | (1) | ECE2015
Management of thyroid eye disease
The diagnosis of TED is not always obvious and its management can be a challenging. Diagnosis as well as treatment should be performed in a multidisciplinary setting. Decision on treatment is based on a careful assessment of ophthalmological symptoms and the evaluation of the clinical activity of the disease using the clinical activity score. TED is classified into mild, moderate and sight threatening disease. An active inflammatory disease stage is followed by an inactive sta...
ea0037mte5 | (1) | ECE2015
Central precocious puberty: management and long-term outcome
CPP results from premature reactivation of the hypothalamopituitarygonadal axis and pulsatile GnRH secretion, with a hormonal pattern similar to that of normal puberty. Recent studies have implicated the activation of Kisspeptin and its receptor and the inactivation of MKRN3 genes in CPP. MKRN3 gene defects are currently an identified genetic cause of paternally transmitted familial CPP, but such defects do not underlie maternally transmitted CPP and are rarely inv...
ea0037mte6 | (1) | ECE2015
Management of the transgender patient
Gender dysphoria (GD) is a condition in which a person experiences discongruency between their assigned sex and what they feel their genderidentity is. A person with gender dysphoria experiences persistently uncomfortable feelings about their birth gender (Diagnostic and Statistical Manual of Mental Disorders, Fifth edition (DSM-V) (American Psychiatric Association).During the real life experience hormonal treatment usually starts and applica...
ea0037mte7 | (1) | ECE2015
Management of adrenal insufficiency
For a long time it has been assumed that patients with adrenal insufficiency (AI) can live without any restriction when receiving standard hormone replacement therapy.However, recent evidence indicates that subjective health status (SHS) in patients with primary adrenal insufficiency is significantly impaired at least in a subgroup of patients and that mortality is increased compared to the general population.The observation of imp...
ea0037mte8 | (1) | ECE2015
Acromegaly and cancer
Experimental and epidemiological studies have implicated high serum GH and IGF1 levels as potential contributors to tumor progression by both endocrine and paracrine mechanisms. It is still a matter of debate, however, if the prevalence of cancer is increased in acromegaly, as this disorder, characterized by chronic GH and IGF1 hypersecretion, is also associated with elevated IGFBP3 levels, which has proapoptotic and anti-proliferative protective effects. On the other hand, no...
ea0037mte9 | (1) | ECE2015
Management of craniopharyngioma
The experience of patients with craniopharyngioma is not benign; these patients are subject to increased mortality compared to age- and gender-matched peers and increased morbidity from hypopituitarism, obesity, thirst and electrolyte disorders and sleep disturbance. This talk will explore the challenges specific to management of this patient cohort, how they differ from other patients with tumoural hypopituitarism, strategies to minimize hypothalamic damage and how to assess ...
ea0037mte10 | (1) | ECE2015
Approach to the patient with dyslipidaemia
In clinical practice, dyslipidaemia defines the elevated plasma total cholesterol, LDL cholesterol or triglycerides or the decreased HDL cholesterol levels. In recent years however, new laboratory methods helped us understand that the functions of lipoproteins are more important than their amounts. Dyslipidaemia is one of the most important and correctable risk factors for the atherosclerotic cardiovascular diseases (CVD). The epidemiological data recurrently show a very signi...
ea0037mte11 | (1) | ECE2015
MTE 13: management of male osteoporosis
Osteoporosis in men is recently recognized as a major underestimated public health problem. In 2050, the incidence of hip fracture in men is expected to increase by 310% worldwide. After the age of 50, one out of three osteoporotic fractures are seen in men. Men suffering any major fracture have a higher mortality rate than women osteoporotic fractures. Screening is usually recommended in many guidelines above the age of 65 or 70 years and those younger aged with risk for oste...
ea0037mte12 | (1) | ECE2015
Medullary thyroid cancer
Medullary thyroid cancer (MTC) is a rare disease accounting for about 5% of all thyroid cancers and can occur sporadically (75%) or as part of the familial syndrome multiple endocrine neoplasia type 2 (MEN 2). The hereditary forms are caused by a mutation in the rearranged during transfection (RET) gene.When a proven RET mutation is present carriers will be offered a prophylactic thyroidectomy. The timing of this prophylactic procedure is not...
ea0037mte14 | (1) | ECE2015
Meet the expert 17 (MTE17): management of Turner syndrome
The complete or partial absence of one of the two X chromosomes in a female with characteristic phenotype appearance entitles to Turner syndrome (TS) diagnosis. Monosomy of X chromosome (45,X) is prevalent, however some patients are mosaic and carry one or more additional cell lines, also with Y chromosome. The karyotype variability reflects the wide clinical spectrum of the syndrome. The prevalence of spontaneous puberty is 6% for 45,X and more than 50% for other karyotypes. ...
ea0037mte15 | (1) | ECE2015
Primary hyperparathyroidism (Meet-the-Expert 18)
Primary hyperparathyroidism (PHPT) is the third common disorder of the endocrine system. It reaches a peak incidence between ages 5060. Biochemical screening has increased its incidence up to one per 1000 (USA), and most cases are presented with asymptomatic mild hypercalcemia. The most common cause in affected individuals is a functioning single parathyroid adenoma. In advanced cases, bones (brown tumours, osteitis fibrosa cystica) and the kidney (nephrolithiasis, nephr...
ea0037mte16 | (1) | ECE2015
Assessing osteoporosis in the young adult
Fragility fractures in the young individual are an uncommon clinical scenario and when faced with such a situation, appropriate assessment is required to ensure correct diagnosis of the underlying aetiology and to avoid unnecessary interventions. Although, primary causes of osteoporosis such as osteogenesis imperfecta are considered rare, this group of conditions has considerable phenotypic and genotypic heterogeneity and may be underdiagnosed. However, the majority of the you...
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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