Endocrine Abstracts

Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder characterized by hyperandrogenism in women, with a high incidence of insulin resistance. Decanoic acid (DA), a naturally occurring 10-carbon fatty acid, has been shown to improve insulin sensitivity and lipid profile in an in vivo model of diabetes without the induction of weight gain. However, the effects of DA on androgen production has not been explored.Aim: The objective o...

Introduction: Lipid accumulation product (LAP) has been validated as good surrogate marker for the presence of metabolic syndrome (MetS) in general population. The aim of this study was to evaluate LAP in different PCOS phenotypes and to determine its association with MetS.Methods: We evaluated 365 PCOS women (PCOS: 25.05±6.24−kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (contro...

The gonadotropic hormones, LH and FSH are critical regulators of normal sexual functions including steroidogenesis and gametogenesis. Their essential role is underscored by the development of various hypogonadal phenotypes arising from genetic mutations. Constitutive activation of their cognate receptors also disturbs their function. We earlier showed that transgenic expression of an activating mouse Fshr mutant (mFSHRD580H) in granulosa c...

Background: During ageing, total testosterone (TT) declines and SHBG increases, resulting in a greater decline of free testosterone (FT) compared to TT. However, guidelines suggest using TT to diagnose androgen deficiency and to reserve FT only for men with borderline TT. We investigated if isolated low FT or isolated low TT was associated with androgen-related endpoints in healthy men.Methods: 3369 community-dwelling men, aged 40–79, were included....

Epithelial–mesenchymal transition (EMT) is an important process appeared in tumour migration or progression, which is activated by 17β-estradiol (E2). As a typical endocrine disrupting chemical (EDC), bisphenol A (BPA) has a potential to promote EMT and migration of oestrogen responsive cancers. On the contrary, genistein (GEN) as a phytoestrogen is known to have chemopreventive effects in diverse cancers. In the present study, the effects of BPA and GEN o...