Endocrine Abstracts

It is known that high levels of TSH are associated with higher miscarriage risk, though the precise TSH cut-offs are debated. Aim of the present study was to evaluate if pre-conceptional TSH levels associate with increased risk of early miscarriage in a large series of infertile women submitted to IVF and to determine the threshold of TSH associated with the highest prevalence of pregnancy loss. We retrospectively studied 1484 infertile women (mean±age 36.7±4.1 years...

Kisspeptin is found in the ovary of different species including human and rat. We have recently described, through in vitro studies, that kisspeptin is under the control of sympathetic innervation of the ovary. Considering that ovarian activity of sympathetic nerves increases with ageing, it is possible that the ovarian kisspeptin also increases during this period. As a role of kisspeptin in folliculogenesis has been postulated, this increase in kisspeptin could parti...

Objective: The aim of our study is to determine clinical factors and sonographic findings associated with endometrial hyperplasia or cancer (EH+) in pre- and perimenopausal women.Study design: A total of 14 340 transvaginal ultrasonography examinations of 9 888 healthy pre- and perimenopausal women were included in this retrospective study. One hundred sixty-two subjects underwent endometrial biopsy based on abnormal uterine bleeding (AUB), sonographic e...

Background: The melanocortin system is known to be involved in hypothalamic regulation of energy balance, which is implicated in reproductive success. However, the peripheral role for melanocortin receptor (MCR) signalling in the reproductive system has not been described. During a clinical trial of repeated high dose tetracosactide (ACTH1–24) injection, four of nine premenopausal women with Addison’s disease developed menstrual disturbances. We wondered i...

Introduction: The pathogenesis of idiopathic hirsutism (IH) is not clear. On the other hand, human skin possesses all the enzymes necessary for androgen synthesis and catabolism indicating that it is an independent peripheral endocrine organ. Thus, in the present study we aimed to investigate the mRNA expression of aromatase enzyme and the other enzymes having functional roles in the steroidogenic pathway, in freshly obtained skin tissue from subumblical skin and the arm of wo...

Inconsistences in hirsutism evaluation using The Modified Ferriman-Gallwey scale (mFG) between different evaluators and need for hirsutism diagnostics standardization has been reported in numerous publications.The aim of the study was to determine the differences in the evaluation of female hirsutism between researchers.Results: The study included healthy 20–34 year old (mean age 25.2 years, 95% CI 23.8–26.5) women with r...

Introduction: Incretins are peptide hormones, responsible for 70% of the insulin release after oral glucose intake. An impaired incretins secretion was noted in several conditions involving insulin resistance, including polycystic ovary syndrome (PCOS), known as the state with increased testosterone level. This paper considers a possible relationship between the level of free androgen index (FAI) and glucose-dependent insulinotropic peptide (GIP) among lean women affected by P...