Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

Guided Posters

Calcium, Vitamin D and Bone

ea0037gp.10.01 | Calcium, Vitamin D and Bone | ECE2015

Roles of membrane oestrogen receptor alpha in bone sparing effects of oestrogens

Vinel Alexia , Fontaine Coralie , Hay Eric , Valera Marie , Lenfant Francoise , Cohen-Solal Martine , Arnal Jean-Francois

Introduction: The bone-sparing effect of oestrogen is mediated via oestrogen receptor alpha (ERα), which stimulates transcriptional action through its two activation functions (AF1 and AF2). In addition to these nuclear effects, a fraction of this receptor is targeted to the plasma membrane and triggers membrane initiated steroid signaling (MISS). Whereas, ERα AF1 plays a crucial role in trabecular bone, but not cortical bone, ERα AF2 is necessary for the oestro...

ea0037gp.10.02 | Calcium, Vitamin D and Bone | ECE2015

Comparison of two methods in assessment of fracture risk of postmenopausal women with osteopenia

Kuzma Martin , Nemethova Eva , Killinger Zdenko , Payer Juraj

Introduction: More than half of osteopenic patients suffer from fracture (Fx), but BMD osteopenia is usually not considered for treatment initiation. FRAX, tool that can identify patients with high Fx risk based on major risk factors, can be used as an interventional threshold. Past few years, trabecular bone score (TBS), the bone quality determinant, is a promising method identifying the high-risk patients according to degradation of trabecular bone.Obj...

ea0037gp.10.03 | Calcium, Vitamin D and Bone | ECE2015

Local administration of non-diabetic MSCs to diabetic femoral fractures enhances callus remodelling and deposition of reparative bone

Watson Luke , Chen Xi Zhe , Ryan Aideen , Loftus Paul , McDonnell Patrick , O'Brien Timothy , Coleman Cynthia

Fractures in diabetic patients are slower to heal and have an increased risk for developing malunion as compared to non-diabetic individuals. Given the known deficiencies in diabetic progenitor cell number and differentiation capacity, it is reasonable to hypothesise the aetiology of diabetic fracture malunion is dysregulated progenitor function. Therefore, we investigated the therapeutic efficacy of locally administered non-diabetic human bone marrow derived mesenchymal stem ...

ea0037gp.10.04 | Calcium, Vitamin D and Bone | ECE2015

Osteoporosis and osteopenia in patients after kidney and pancreas transplantation

Brunova Jana , Kratochvilova Simona , Bruna Josef

Background: Organ transplantation (Tx) is the standard treatment for end-stage renal failure in diabetic patients. With an improvement in patient and graft survival, the bone loss and persistent abnormalities in bone metabolism are long-term complications to manage.Patients and methods: We investigated the prevalence of osteoporosis and osteopenia in 256 diabetic patients (142M, 114F) after the kidney and pancreas Tx for renal failure due to diabetic nep...

ea0037gp.10.05 | Calcium, Vitamin D and Bone | ECE2015

Effect of 1-year cross-sex hormonal treatment on bone mineral density of the lumbar spine in transgender patients

Vlot Mariska , Klaver Maartje , Lips Paul , de Jongh Renate , Heijboer Annemieke , den Heijer Martin

Background: Oestrogen can increase bone mineral density (BMD) by decreasing bone turnover, which is mainly seen in trabecular bone. Testosterone can increase bone size, but the effect on BMD is less clear. Cross-sex hormonal treatment (CSHT) in transsexuals can therefore affect the BMD. For example, in male-to-female individuals (MtFs) a lower BMD before start of CSHT has been described in comparison to healthy control men.Objectives: To investigate the ...

ea0037gp.10.06 | Calcium, Vitamin D and Bone | ECE2015

The (CAG)n repeat polymorphism of the androgen receptor gene is associated with bone mineral density in menopausal women

Markatseli Anastasia , Lazaros Leandros , Kostoulas Harilaos , Markoula Sofia , Tigas Stelios , Georgiou Ioannis , Tsatsoulis Agathocles

Introduction: Osteoporosis is a systemic skeletal disease with a strong genetic component. The androgen receptor (AR) is encoded by the AR gene and mediates the action of androgens, which play an important role in bone metabolism. Polymorphisms in the AR gene may be implicated in the pathogenesis of osteoporosis.Objectives: The present study aimed to explore the influence of the (CAG)n repeat polymorphism of AR</em...

ea0037gp.10.08 | Calcium, Vitamin D and Bone | ECE2015

Role of vitamin D levels and vitamin D supplementation on bone mineral density in Klinefelter syndrome

Ferlin Alberto , Selice Riccardo , Di Mambro Antonella , Ghezzi Marco , Caretta Nicola , Foresta Carlo

Introduction: Decreased bone mineral density (BMD) in Klinefelter syndrome (KS) is frequent and it has been traditionally related to low testosterone levels. However, low BMD can be observed also in patients with normal testosterone levels and testosterone replacement therapy does not necessarily increase bone mass in these patients. Nothing is known about vitamin D levels and supplementation in KS. In this study we determine vitamin D status and bone mass in KS subjects and c...

ea0037gp.10.09 | Calcium, Vitamin D and Bone | ECE2015

Serum cystatin C levels were correlated with cardiometabolic features and cardiovascular diseases in patients with primary hyperparathyroidism

Verdelli Chiara , Ermetici Federica , Filopanti Marcello , Verga Uberta , Passeri Elena , Dito Giorgia , Malavazos Alexis Elias , Mapelli C , Raggi M E , Corbetta Sabrina

Patients with primary hyperparathyroidism (PHPT) are at risk of chronic kidney disease (CKD). PHPT patients (n=190, 146 females and 44 males, aged 59.7±14.2 years) and non-hypertensive, non-diabetic age- and sex-matched healthy controls were evaluated for serum cystatin C and creatinine. PHPT patients and controls with established CKD were excluded. Serum cystatin C was measured by immunonephelometric assay and calculation of estimated glomerular filtration rate ...

ea0037gp.10.10 | Calcium, Vitamin D and Bone | ECE2015

Phenotype–genotype correlation in a series of 131 patients studied for calcium-sensing receptor gene

Vahe Claire , Odou Marie-Francoise , Desailloud Rachel , Leroy Clara , Bauters Catherine , Scherpereel Arnaud , Pattou Francois , Carnaille Bruno , Wemeau Jean-Louis , Vantyghem Marie-Christine

Calcium-sensing receptor gene (CASR) loss-of-function mutations lead to familial hypocalciuric hypercalcaemia (FHH), neonatal severe hyperparathyroidism, and primary hyperparathyroidism. FFH is characterized by mild hypercalcaemia, hypocalciuria, calcium clearance/creatinine clearance (CaCl/CrCl) <0.01, normal or high PTH level. Nevertheless the phenotype may vary (Thakker 2012). The aim of this work was to compare the phenotypes of patients bearing or not a pathogenic <em...