Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

Guided Posters

Diabetes and obesity – basic

ea0037gp.15.01 | Diabetes and obesity – basic | ECE2015

Topical application of CD362+ human mesenchymal stem cells (cyndacel-M) seeded in Excellagen scaffold augments wound healing and increases angiogenesis in a diabetic rabbit ulcer model

Patil Swapnil , Chen Xizhe , Watson Luke , Loftus Paul , Flynn Lisa O' , Chandler Lois , Rubanyi Gabor , Elliman Stephen , O'Brien Timothy

Non-healing foot ulcers are a major complication in diabetic patients. Mesenchymal stem cells (MSCs) are known to promote angiogenesis with improved wound healing. Orbsen Therapeutics has identified a novel antibody (CD362+) which can be used to prospectively FACS-isolate CD362+CD45− MSC from human bone marrow with enhanced MSC/MNC purity ratios of up to 1/4. Excellagen matrix was used to seed the cells as biomaterials are well reported t...

ea0037gp.15.02 | Diabetes and obesity – basic | ECE2015

Sex hormone-binding globulin protects against non-alcoholic fatty liver disease

Lopez Cristina Saez , Barbosa-Desongles Anna , Hernandez Cristina , Dyer Roger A , Innis Sheila M , Rafael Simo , Selva David M

Low plasma sex hormone-binding globulin (SHBG) levels are present in patients suffering chronic metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). However, whether altered SHBG production plays a role in development and progression of this disease is unclear. To investigate SHBG involvement in NAFLD, we studied the effects of overexpressing SHBG in two mouse models, a genetically-induced model, by developing a double transgenic mouse by crossing the human...

ea0037gp.15.03 | Diabetes and obesity – basic | ECE2015

Cardiomyopathy in the male obese diabetic db/db mice is alleviated by oxytocin treatment

Gutkowska Jolanta , Plante Eric , Menouar Ahmed , Chiasson Jean-Louis , Jankowski Marek

Oxytocin (OT) is involved in the regulation of energy metabolism and in the activation of cardio-protective mechanisms. We evaluated whether chronic treatment with OT could prevent the metabolic and cardiac abnormalities associated with diabetes and obesity using the db/db mice model. Four-week-old male db/db mice and their lean non-diabetic littermates (db/+) serving as controls were treated with OT (125 ng/kg per h) or saline vehicle for a period of 12 weeks. Compared to db/...

ea0037gp.15.04 | Diabetes and obesity – basic | ECE2015

Novel human resistin antagonist (monomeric C6A mutant) reduced body weight gain and restored insulin responsiveness in mice fed high fat diet

Benomar Yacir , Solomon Gili , Amine Hamza , Othmane Ahlem , Gertler Arieh , Taouis Mohammed

Resistin promotes both inflammation and insulin resistance associated with energy homeostasis impairment. Resistin is secreted by adipose tissue and macrophages, but its mechanism of action remained unknown because its receptor was not characterised. Recently, we have shown that central resistin acts by way of hypothalamic TLR4 receptors promoting overall inflammation and insulin resistance. Here, we aim to block resistin action in HFD mice that are prone to obesity and inflam...

ea0037gp.15.05 | Diabetes and obesity – basic | ECE2015

Stable analogues of the dual agonist dogfish glucagon show better therapeutic potential than exendin-4 in diet induced obese diabetic mice

O'Harte Finbarr P M , Ng Ming T , Conlon J Michael , Flatt Peter R

Recent acute in vivo studies have shown that structural modifications of dogfish glucagon improves peptide stability and these analogues can act as dual agonists at both glucagon and GLP-1 receptors. Here, we compared the effects of chronic (51 days) twice daily administration of [D-Ala2]dogfish glucagon (Pep-N) and [D-Ala2]dogfish glucagon-exendin-4(31–39) construct (Pep-C), exendin-4(1–39) or saline treat...

ea0037gp.15.06 | Diabetes and obesity – basic | ECE2015

Activation of GPR120 by lipid agonists modulates glucagon secretion in pancreatic islets and improves glucose tolerance in mice

Gormley Noella , Flatt Peter , McKillop Aine

GPR120 is a rhodopsin-like GPCR that has a high affinity for long-chain saturated fatty acids 14–18 carbons and unsaturated fatty acids 16–22 carbons. The beneficial effects of GPR120 on β-cell function and glucose homeostasis have recently been reported however its role in glucagon secretion is unknown. GPR120 and glucagon expression were examined by double immunohistochemical studies using a glucagon secreting cell line (α-TC1.9) and pancreatic tissue fro...

ea0037gp.15.07 | Diabetes and obesity – basic | ECE2015

Nephroprotective properties of metformin and vildagliptin: experimental facts in type 2 diabetes

Bayrasheva Valentina , Grineva Elena , Babenko Alina , Dmitriev Yurii , Shatalov Ivan , Chefu Svetlana , Ivanova Alexandra

Background: Recent studies have demonstrated antioxidant and anti-inflammatory properties of metformin and vildagliptin, that could result in some positive effects on kidney function in diabetes. Indeed, in our previous study vildagliptin attenuated routine renal dysfunction markers in insulinopenic diabetic rats, however metformin didn’t improve it. In our current study we evaluated not only glomerular dysfunction marker (albuminuria), but also novel markers of proximal ...