Endocrine Abstracts

Introduction: Work-up of thyroid nodules remains challenging. At present, many patients with thyroid nodules are referred to surgery for diagnostic rather than therapeutic purposes. Therefore, the value of non-invasive diagnostic methods to optimize the selection of patients for surgery is needed. Strain elastography (SE) enables the determination of tissue elasticity and has shown promising results for the differentiation of thyroid nodules.Methods: The...

Introduction: The incidence of occult lymph node metastases (LNM) in papillary thyroid carcinoma (PTC) reaches 80%, still their surgical management in clinically node negative (cN0) patients remains controversial and ranges from ‘wait and see’ principle to prophylactic dissections of both central and lateral neck compartments. This encouraged some authors to apply the concept of sentinel lymph node biopsy (SLNb) in PTC. Our aim to investigate if SLNb using methylene ...

Introduction: Thyroglobulin plays a vital role in the follow-up of patients with differentiated thyroid carcinoma (DTC) after thyroidectomy combined with radioiodine (RAI) ablation. As to preablative stimulated thyroglobulin (ps-Tg), though several studies have manifested its potential in identifying distant metastatic DTC (DM-DTC), it remains unclear whether a single ps-Tg is sufficient for predicting DM-DTC. This retrospective study was aimed to evaluate the utility of seria...

Introduction: Fine-needle aspiration biopsy (FNAB) of the thyroid gland is an accurate diagnostic test used routinely in the initial evaluation of nodular thyroid disease. A sizeable subset of patients are found to be taking antithrombotic and/or anticoagulant (AT/AC) medications. This creates a dilemma for the endocrinologist, who must weigh the risk of withholding these medications (and the associated potential benefit of diagnosis) against the perceived increased risk of ia...

Aim: Differentiated thyroid cancer (DTC) is the most commonly seen endocrinological tumour. During the follow up of DTC, serum thyroglobulin (TG) levels, neck ultrasound, fine needle aspiration biopsy (FNAB) of the suspicious lymph nodes are important tools. TG washout of the suspicious lymph node as well as the FNAB can detect metastasis and recurrences earlier. In this study we aimed to show the diagnostic role of TG washout of suspicious lymph node FNAB which is not routine...

Objective: 18F-FDG-avid differentiated thyroid cancers (DTC) have been known to behave more aggressively, especially in metastatic sites (flip-flop phenomenon). However, the clinical behaviour of DTC detected incidentally by FDG–PET (PET incidentaloma) has been sparsely reported. We wanted to know whether flip–flop phenomenon is applicable in PET incidentalomas.Methods: 165 DTC patients who underwent thyroid surgery and had pre-operative FDG&#1...

Introduction: Follicular tumours of the thyroid gland include benign follicular adenomas, follicular carcinomas and the follicular variant of papillary carcinoma. Although, molecular markers are a promising area of research to differentiate thyroid neoplasms, there is ample room for improvement in the research and clinical applications in this field. Furthermore, the final diagnosis requires thyroid lobectomy. The present study examined whether a differential protein expressio...

Objectives: Medullary thyroid carcinoma (MTC) has varying clinical course with familial cases (fMTC) diagnosed earlier than sporadic ones (sMTC). We examined the presentation of these entities in our centre.Methods: 223 MTC patients (familial: 42.6%, males: 36.8%) were followed for 0.9–30 years (mean 6.23±5.9, median 4.0 years). 44 (19.7%) fMTC patients were operated after genetic screening.Results: Median age at diagnosi...

Introduction: In patients with well-differentiated thyroid cancer (DTC) low/undetectable thyroglobulin (Tg) at time of remnant ablation usually reflects a complete previous surgery. However, in a small percentage (6.3–16%) it can represent false negative values.Objectives: Evaluate the frequency of patients with low/undectable Tg at time of remnant ablation with locoregional or distant lesions at post-ablative 131I whole body scan (WBS) a...