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Endocrine Abstracts (2015) 37 EP751 | DOI: 10.1530/endoabs.37.EP751

1Department of Neurosurgery, Central Military Hospital, 1st. Medical Faculty of Charles University, Prague, Czech Republic; 2Department of Internal Medicine, General Teaching Hospital, 1st Medical Faculty of Charles University, Prague, Czech Republic.


Introduction: In the past 10 years, endoscopic resection of pituitary adenomas has become an alternative to microsurgical resection with the additional advantage of increasing the patient’s postoperative comfort. This analysis explored whether endoscopic resection can reduce the risk of postoperative neurohypophyseal dysfunction.

Material and methods: We rated and compared the need to administer desmopressin during the first four postoperative days and with the need after a follow-up of at least 3 months (chronic administration). Two groups of patients were compare: Patients in group 1 were operated on microscopically. Patients in group 2 were operated on endoscopically. Group 1 was made up of 50 patients treated in 1999, group 2 comprised 50 patients operated on from 2006 to 2007.

Results: In group 1 the need to use desmopressin postoperatively occurred in eight patients: three needed chronic treatment. In group 2 the need for postoperative application of desmopressin occurred in four patients, none required chronic treatment.

Conclusions: Endoscopic surgery is a safe and effective method for the resection of pituitary adenomas. The rate of chronic desmopressin application was reduce.

Disclosure: NT13631-4.

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