Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2015) 37 EP11 | DOI: 10.1530/endoabs.37.EP11

ECE2015 Eposter Presentations Adrenal cortex (94 abstracts)

Aldosterone- and cortisol-co-secreting adrenal adenoma in an adolescent girl: a case report

Serap Baydur Sahin 1 , Ahmet Hamdi Aktan 2 , Osman Zikrullah Sahin 3 , Ahmet Fikret Yucel 4 & Ekrem Algun 1


1Department of Endocrinology and Metabolism Disease, Recep Tayyip Erdogan University Medical School, Rize, Turkey; 2Department of Internal Medicine, Recep Tayyip Erdogan University Medical School, Rize, Turkey; 3Department of Nephrology, Recep Tayyip Erdogan University, Rize, Turkey; 4Department of General Surgery, Recep Tayyip Erdogan University, Rize, Turkey.


Introduction: Primary aldosteronism (PA) is the most common reason for secondary hypertension. Among adrenal disorders, rarely aldosterone- and cortisol-co-secreting adenomas (A/CPA) can lead to PA. 35 patients with A/CPA were reported to date and their mean age was 52 (range 34–80) years. We report an A/CPA in an adolescent girl presenting with hypertension combined with hypokalemia and signs of hypercortisolism.

Case report: A 18-year-old girl admitted to endocrinology outpatient clinic with the complaint of hypertension. Physical examination revealed central obesity (BMI:31 kg/m2), moon face, hirsutism, buffalo hump and abdominal striae. Her blood pressure was 170/110 mmHg. Laboratory examination revealed serum potassium level of 2.4 mEq/l. The mean aldosterone to renin ratio was 308 (aldosterone: 98.77 ng/dl, plasma renin activity (PRA): 0.32 ng/ml per h). Intravenous saline infusion test was performed as the confirmatory test. Her post-infusion aldosterone level was 80.69 ng/dl. While the midnight serum cortisol level was 7.6 μg/dl, her serum cortisol levels failed to suppress during a 1 mg dexamethasone suppression test (DST) (5 μg/dl) and 2 mg DST (9.8 μg/dl). Serum ACTH and DHEA-S levels were 13.1 pg/ml and 11.12 μg/dl (n: 65–368) respectively. Computed tomography of adrenal glands revealed a 24×14 mm hypodense solid lesion in the right adrenal gland. She underwent laparoscopic right adrenalectomy with perioperative steroid replacement. At the postoperative day 4 at 0800 h, serum cortisol level was 0.6 μg/dl and she was put on substitution therapy with oral glucocorticoids. The aldosterone level and PRA were 2.12 ng/dl and 5.59 ng/ml per h 2 days after the operation, respectively. At the follow-up, her blood pressure and serum potassium level returned to normal.

Conclusion: Patients with A/CPA may present with overt or subclinical hypercortisolism. Therefore, pre-operative screening of cortisol co-secretion in patients with aldosterone-producing adenomas is important to prevent adrenal crises at the perioperative period.

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