ECE2015 Eposter Presentations Endocrine tumours (69 abstracts)
Evaluation of routine basal serum calcitonin measurement for an early diagnosis of medullary thyroid carcinoma
Entela Puca 1 , Kadir Burak Koza 1 , Emiljana Huti 1 , Sonila Bitri 1 , Albana Daka 1 , Edmond Puca 2 & Agron Ylli 2
1American Hospital 2, Tirana, Albania; 2UHC Mother Teresa, Tirana, Albania.
Background: Medullary thyroid carcinoma (MTC) is characterised by a high concentration of serum calcitonin. Routine measurement of serum calcitonin concentration has been advocated for detection of MTC among patients with nodular thyroid diseases. The aims of our study were to identify medullary thyroid cancer (MTC) in its earliest stages by screening patients with basal calcitonin measurements and to determine whether basal serum calcitonin measurements should be a part of our routine evaluation of a nodular goitre.
Subject and methods: We performed routine measurement of basal serum calcitonin levels from 151 patients (male 30 and female 121 with nodular goitre. The average age was 47 years old (range 19–76).
Results: Patients with FNAC or ultrasound suspicious of any kind of thyroid carcinoma and patients with elevated basa calcitonin level underwent surgery. Three patients (1.9%) had elevated basal serum calcitonin levels ranging between 129 and 7493 pg/ml. FNAC was suggestive of MTC in two from three patient with elevated calcitonin. MTC was confirmed in all patients, with elevated calcitonin. Differentiated thyroid carcinoma, mostly papillary, was confirmed at histology in 40 subjects. The prevalence of MTC, diagnosed by serum CT measurement among 136 patients with nodular thyroid disease was high: 1.9% of all thyroid nodules and 7% of all thyroid carcinomas. Serum CT measurement was superior to FNAC in suggesting the diagnosis of MTC.
In conclusion, calcitonin measurement is an effective method for the diagnosis of MTC. It is superior to FNAB for diagnosis of MTC. High basal serum calcitonin levels increase the chance of curative therapy by diagnosing it in the early stages.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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