Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2015) 37 EP385 | DOI: 10.1530/endoabs.37.EP385

1Clinic for Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, Belgrade, Serbia; 2Emergency Center, Clinical Center of Serbia, Belgrade, Serbia.


Introduction: Different surgical procedures are followed by alteration in insulin sensitivity. The aim of our investigation was to analysed the influence of major (open cholecystectomy) and minor surgical stress (laparoscopic cholecystectomy) on insulin resistance.

Methods: Insulin resistance was calculated by HOMA-IR before surgery and at 1st, 3rd, and 7th day after the elective operations. All participants were divided in two groups: group A with open cholecystectomy n=20; 38.8±4.3 years of age; mean BMI 26.9±1.6 kg/m2 and group B with laparoscopic cholecystectomy; n=20; 39.8±4.5 years of age; mean BMI 26.8±1.9 kg/m2.

Results: There were no difference in HOMA-IR between groups A and B before surgery (mean 2.5±0.33 vs 1.99±0.70; P>0.05) as well as the 1st day after surgery (2.55±0.62 vs 1.85±0.58; P>0.05). HOMA-IR was higher in group B 3rd day after operation than in group A (7.56±2.34 vs 2.8016±0.78; P<0.05). There were no difference between two groups 7 days after surgery (0.65±0.45 vs 0.74±0.40; P>0.05).

Conclusion: Open and laparoscopic cholecystectomy are followed by transient insulin resistance which become normal a week after the operation. Laparoscopic cholecystectomy less deteriorate insulin sensitivity in response to stress than open approach.

Article tools

My recent searches

No recent searches.

My recently viewed abstracts