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Endocrine Abstracts (2015) 37 EP594 | DOI: 10.1530/endoabs.37.EP594

1Belarusian State Medical University, Minsk, Belarus; 2Minsk Cancer Center, Minsk, Belarus; 3Minsk Endocrinology Center, Minsk, Belarus.


Introduction: Patients with primary hyperparathyroidism (PHPT) have an increased cardiovascular risk. However, the data on the relationship severity of PHPT clinical forms and prevalence of cardiovascular disorders are controversial.

Objective: Studying cardiovascular disease in patients with manifested forms of PHPT compared with mild forms.

Materials and methods: We studied 136 patients with PHPT (assesses arrhythmias, hypertension, coronary disease), a general medical examination were made. The indicators calcium and phosphorus metabolism (PTH, vitamin D, Ca general, Ca++, phosphates) were investigated.

Results: The mild PHPT were diagnosed in 54 patients with a mean age of patients was 51.5±11.6 years, manifested forms PHPT were diagnosed in 82 patients, the average age of the patients was 52±10.4 years. Cardiovascular disease were found in 19 (35.1%) patients with mild forms of PHPT and 38 (45.2%) with the manifested PHPT. A strong statistically significant correlation between the severity of clinical manifestations PHPT and incidence of cardiovascular disease in patients with PHPT (R=0.81, P<0.05).

Conclusion: These results suggest the high incidence of cardiovascular disease in patients with manifested PHPT and the low diagnostic rate of mild forms of PHPT.

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