ECE2015 Eposter Presentations Pituitary: clinical (121 abstracts)
The impact of diabetes mellitus on the survival of patients with acromegaly
Wen-Ko Chiou 1 , Szu-Tah Chen 2 , Feng-Hsuan Liu 2 , Chen-Nen Chang 2 , Ming-Hsu Wang 1 & Jen-Der Lin 2
1Chang Gung University, Taoyuan Hsien, Taiwan; 2Chang Gung Memorial Hospital, Taoyuan Hsien, Taiwan.
Aims: An increased risk of mortality in patients with uncontrolled acromegaly has been reported in several studies. We aimed to assess the impact of co-morbidities on the survival of patients with acromegaly after long-term treatment and follow-up.
Methods: A retrospective analysis was performed for 285 patients with active acromegaly who were admitted to the Chang Gung Memorial Hospital, Taiwan between 1978 and 2012.
Results: Of these patients, 106 (37.2%) were diagnosed with diabetes mellitus (DM). During the follow-up period, 21 cases of histological proved malignant in acromegalic patients, and DM with acromegaly had a higher incidence of malignancy (13.2% vs 3.8%; P<0.01). The 5-, 10-, and 20-year survival rates were 93.1, 86.9, and 84.7% for the DM group, respectively, and 96.7, 96.7, and 96.7% for the non-DM group, respectively. After a mean follow-up of 15.1±0.6 years, age, DM, coronary heart disease, and malignancy were found to be significant factors of mortality. Control of growth hormone and IGF-1 levels also conferred a marginal survival benefit.
Conclusions: DM and malignancy significantly influence the survival of patients with acromegaly; thus, these patients need close follow-up and appropriate therapy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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