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Endocrine Abstracts (2015) 37 EP875 | DOI: 10.1530/endoabs.37.EP875

1Endocrinology, Puerta del Mar Hospital, Cádiz, Spain; 2Pathological Anatomy, Puerta del Mar Hospital, Cádiz, Spain; 3Radiology, Puerta del Mar Hospital, Cádiz, Spain.


Background: Fine-needle aspiration (FNA) biopsies are the cornerstone of preoperative evaluation of thyroid nodules, but FNA diagnostic performance has varied across different studies. We conducted a study to evaluate the effectiveness of ultrasound guided FNA in the thyroid nodule and to review the correlation between cytopathology and histopathology.

Methods: Prospective FNAs were collected from 332 patients who underwent thyroid surgery between 2008 and 2013. The cytological sample was assessed by a single consultant pathologist and was classified as inadequate, non-neoplastic, neoplastic, or indeterminate. The histology were classified as non-neoplastic (benign), neoplastic (malignant). Sensitivity, specificity, positive predictive value, and negative predictive value were calculated.

Results: The mean age was 51.65±13.40 years, 279 (84%) were women. The average size of nodules was 3.35±1.41 cm. Multinodular goiter presented with dominant nodule 239 (72%) patients and 93 (28%) single nodule. Cytology analysis showed 216 (66.3%) benign, 86 (26.4%) indeterminate, and 24 (7.4%) malignant. One hundred and ninety-seven (59.3%) patients underwent total thyroidectomy. From this population indeterminate cytology rate were 75 (87.2%) benign and 11 (12.6%) malignant histopathology. The FNAs had a sensitivity of 84.62%, specificity of 99.07%, positive predictive value of 91.67%, and negative predictive value 98.15%.

Conclusions: Ultrasound-guided FNA provides important information for the diagnosis and the preoperative evaluation of thyroid nodules. The low rate of false-positive and false-negative results suggests that it might be enough for surgical planning for thyroid nodule.

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