Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2015) 38 P224 | DOI: 10.1530/endoabs.38.P224

SFEBES2015 Poster Presentations Obesity, diabetes, metabolism and cardiovascular (108 abstracts)

The hypoglycaemic and antioxidant properties of oleanolic acid ameliorate blood pressure and kidney function of experimental animals

Andile Khathi , Bonisiwe Mbatha & Cephas T Musabayane


University of KwaZulu-Natal, Durban, South Africa.


The wide range of phytochemicals in medicinal plants serves as sources of bioactive compounds for treatment diabetic complications. We investigated whether Syzygium aromaticum-isolated oleanolic acid (OA) has beneficial effects on some diabetic complications in STZ-induced diabetic rats. We used experimental models of hypertension [spontaneously hypertensive (SHR) and Dahl salt-sensitive (DSS)] rats to explore the effects of OA on mean arterial blood pressure (MAP) and renal function. Selected biochemical parameters were also assessed in blood, muscle and liver samples from diabetic rats treated with OA for 5 weeks. The effects of a 9-week OA administration on MAP and kidney function were monitored in normotensive Wistar, SHR and DSS rats. In addition, anti-oxidative effects of OA on cardiac, hepatic and renal tissues were examined in all groups. Renal proximal tubular effects of OA on Na+ handling were studied in anaesthetized Wistar rats challenged with hypotonic saline after a 3.5 h equilibration for 4 h of 1 h control, 1.5 h treatment and 1.5 h recovery periods using lithium clearance. OA was added to the infusate during the treatment period. Untreated diabetic rats exhibited hyperglycaemia, oxidative stress, depleted hepatic and muscle glycogen concentrations which were restored to near normalcy by OA treatment. OA administration elicited hypotensive responses in all groups of animals which were more marked in hypertensive animals and correlated positively with increased urinary Na+ excretion. Acute infusion OA increased FENa and FELi without influencing GFR indicating that at least part of the overall natriuretic effect involved inhibition of Na+ reabsorption in the proximal tubule. OA treatment reduced malondialdehyde (a marker of lipid peroxidation) and increased activities of antioxidant enzymes; superoxide dismutase and glutathione peroxidase in hepatic, cardiac and renal tissues in all groups. These results suggest that the hypoglycaemic and antioxidant effects of OA improve some metabolic complications of diabetes.

Volume 38

Society for Endocrinology BES 2015

Edinburgh, UK
02 Nov 2015 - 04 Nov 2015

Society for Endocrinology 

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