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Endocrine Abstracts (2015) 39 EP122 | DOI: 10.1530/endoabs.39.EP122

BSPED2015 e-Posters Thyroid (10 abstracts)

Scottish mothers and babies at Yorkhill (MABY) thyroid health study – preliminary report

Filiz Mine Cizmecioglu 1 , Maira Bouga 2 , Suzanne Fletcher 2 , Sahar Sharif 2 , Guisella Velasquez 2 , Sarah Blaise 2 , Jeremy H Jones 3 , Malcolm Donaldson 2 & Emilie Combet 2


1Kocaeli University and Medical School, Izmit, Turkey, 2University of Glasgow, Glasgow, UK, 3Royal Hospital for Children, Glasgow, UK.


Introduction: Iodine is essential for thyroid hormones synthesis, and fetal/infant neurodevelopment. There is increasing evidence of iodine insufficiency among British women. The MABY study is a longitudinal cohort study assessing the iodine and thyroid status of pregnant women and their offspring.

Methods: Healthy women were recruited (target 697 mother/infant pairs) from antenatal clinics at gestational week (GW) 28±1. Blood and urine were collected at GW 28, 36; and from infant and mother postnatally (week 1). Optional maternal hair and breastmilk samples were collected. A validated iodine-specific food frequency questionnaire (FFQ) was completed at G28 and postnatally. Infant thyroid function was assessed through neonatal capillary TSH and urinary iodine status (UI) by Sandell-Kolthoff method.

Results: Over 6 months, 50% of eligible women approached were enrolled (n=191) (median age 33 years, IQR 30–35). Median (IQR) iodine intake at recruitment (100% FFQ completed) was 142 (94–112) ug/d, up to 191 (121–269) ug/day when iodine-containing supplements (reported by 37%) were included. Urine and blood samples were collected from 99 and 93% (GW28) and 94 and 93% (GW36), respectively. To date, 70 women have given birth, with 62 infants (40F:22M) followed-up (eight excluded based on GW, pregnancy complications or drop-out). Median (IQR) birthweight and gestational age were 3515 g (3275–3899) and 40+2 weeks (39+3–41+1). Postnatal maternal sample/data collection (n=62) was: 97% FFQ, 92% urine, 98% blood, 57% hair and 30% breastmilk. Infant urine and blood spots were obtained from 75 and 77%. Infant TSH results (n=60) showed four (7%) infants >2 mU/l, none >3 mU/l. Preliminary UI analysis indicated a maternal median (IQR) UI of 109 ug/l (54–189) at GW28 (n=58); 150 ug/l (93–231) at GW36 (n=53), and 58 ug/l (19–163) postnatally (n=53). Neonatal UI was 117 ug/l (64–188).

Conclusion: Enrolment and retention for the MABY study is encouraging with >25% of the target number recruited so far. Preliminary data are consistent with other iodine studies in the UK.

Volume 39

43rd Meeting of the British Society for Paediatric Endocrinology and Diabetes

British Society for Paediatric Endocrinology and Diabetes 

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