Endocrine Abstracts

Pancreatic neuroendocrine tumours (PanNETs) are clinically challenging diseases as they display variable outcomes. We performed genome sequencing on 100 sporadic, primary pancreatic neuroendocrine tumours (PanNETs) and defined the underlying mutagenic mechanisms and mutations promoting this rare malignancy. Genome-wide analysis showed PanNETs to have a lower mutation burden and greater genomic stability than pancreatic exocrine cancers. The most common mutational signatures we...

Prof. Scarpa is Chair of the Department of Pathology and Diagnostics and Director of the ARC-Net Research Center for Applied Research on Cancer. He leads the Cancer Biobank Network Programme in the Veneto Region (Italy) (population 4 600 000). Chief of the Diagnostic Molecular Pathology Laboratory officially recognized by Veneto Government as one of two referral centres for cancer related molecular diagnostics in the ...