Endocrine Abstracts

One of the main consequences of vessel pruning and inhibition of neovessel growth produced by angiogenesis inhibitors is increased intra-tumor hypoxia. Nevertheless, growing evidence indicates that tumor cells escape from this hypoxic environment to better nourished locations, presenting hypoxia as a positive stimulus for invasion. Indeed, we and others have described a pro-invasive and pro-metastatic adaptation to VEGFR-targeted antiangiogenic therapy that implicates hypoxia ...

Dr Oriol Casanovas is an internationally renowned laboratory researcher with ample knowledge and expertise in basic and translational research of mouse models of cancer and tumor angiogenesis. His research at ICO-IDIBELL in Barcelona has always been focused on determining the consequences of adaptation and resistance to anti-angiogenic therapies against cancer. His scientific achievements have been published in highly...