Endocrine Abstracts

Objective: Gestational diabetes mellitus (GDM) is a multifactorial disorder with environmental factors and genetic modifiers. IGF2BP2 gene polymorphisms are shown to be involved in T2DM and diabetic nephropathy. Here, we aimed to document the association between IGF2BP2 gene polymorphism and GDM to understand the pathogenesis of GDM.

Design: Matched, case-control study.

Method: Ninety-three patients with GDM and 89 healthy pregnant subjects were involved. IGF2BP2 (rs1470579) polymorphisms were genotyped to examine the association between GDM and IGF2BP2 polymorphism.

Results: Although IGF2BP2 (rs1470579) polymorphism was more frequent in GDM group, this association was not statistically significant (P=0.267). We also examined the association between IGF2BP2 polymorphism and the clinical parameters. Subjects bearing the risk allelle ‘c’ of IGF2BP2 gene had higher LDL levels when compared the genotype aa (P=0.034).

Conclusions: The contribution of the rare genetic variants such as IGF2BP2 (rs1470579) in the development of GDM differs across the ethnicites. Here in this study, IGF2BP2 (rs1470579) was not involved in GDM. The association between IGF2BP2 and LDL cholesterol levels may be attributable to the role of insulin-like growth factor system in lipid metabolism.