Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 41 | ECE2016 | Next issue

18th European Congress of Endocrinology

Symposia

What's new and exciting in nuclear receptor action?

ea0041s25.2 | What's new and exciting in nuclear receptor action? | ECE2016

Ligand independent activities of vitamin D receptor

Laverny Gilles

The bioactive form of Vitamin D [1,25(OH)2D3] plays a major role in calcium homeostasis. Moreover, it has potent anti-inflammatory and anti-proliferative properties, and thus is a potential pharmacological agent to treat various refractory diseases. Nevertheless, the doses required to elicit such effects induce hypercalcemia. The activity of 1,25(OH)2D3 is mediated by the vitamin D receptor (VDR), a member of nuclear receptor superfamily. A number of patients with rickets carr...

ea0041s25.3 | What's new and exciting in nuclear receptor action? | ECE2016

Molecular battles between corticosteroid receptors in the heart

Cidlowski John

Heart failure is a leading cause of death in man, and stress is increasingly associated with adverse cardiac outcomes. Glucocorticoids are primary stress hormones, but their direct role in cardiovascular health and disease is poorly understood. To determine the in vivo function of glucocorticoid signaling in the heart, we generated mice with cardiomyocyte-specific deletion of the glucocorticoid receptor (GR). The cardioGRKO mice appear normal early in life but die pre...