Endocrine Abstracts

Octreotide is first-line medical therapy for patients with acromegaly. Up to 80% of patients are not satisfactorily controlled on octreotide alone and up to 20% have no response. COR-005 (previously DG3173) is a novel somatostatin analogue under investigation for treatment of acromegaly. COR-005 has high affinity for human somatostatin receptor subtypes 2, 4 and 5.The study was designed to assess pharmacokinetics of escalating doses COR-005 sc tid and co...

Introduction: In adult patients with pituitary disease no relationship has been established between the biochemical severity of GHD and the degree of QoL impairment. Reasons may include heterogeneity of underlying pathologies, and the type of therapies received by GHD patients.Methods: The KIMS (Pfizer International Metabolic Database) database was used to focus solely on patients with non-functioning pituitary adenomas and prolactinomas treated by surge...

Background: OPKO Biologics is a clinical-stage public company developing long-acting therapeutic proteins utilizing CTP technology. The technology involves fusion of the C-terminal peptide of human chorionic gonadotropin (hCG), which is highly O-glycosylated, to the target protein. CTP enabled the production of a long-acting human growth hormone (hGH) (MOD-4023), which supports a single weekly injection in growth hormone-deficient patients. MOD-4023 is manufactured as a non-vi...

Metabolic diseases are among the most important diseases in western societies and usually related to obesity. Dietary interventions are recommended for treatment and include both strategies with reduced caloric intake and alterations in macronutrient composition. Metabolism must be assumed to be regulated differently in females and males. In previous studies we demonstrated that low carbohydrate high fat (LCHF) diets affect GH/IGF-I axis in male rats. We know investigated whet...

Background: Normal thyroid function is necessary for the optimal effect of recombinant growth hormone (rhGH) on growth rate. GH therapy in children with GH deficiency (GHD) has yielded conflicting results concerning its impact on thyroid function. Data about patients developing subclinical hypothyroidism (SH) are scanty, but it is thought to be associated with impairment of metabolic profile and lower growth response.Objective: To evaluate the effect of ...

Introduction: Patients with AGHD receiving GH often have comorbidities requiring concomitant treatment. We evaluated patterns of concomitant medication use relative to GH therapy initiation in patients with AGHD.Methods: Patients with AGHD with data on concomitant medications enrolled in NordiNet® IOS (NCT00960128), an international, non-interventional study, receiving GH (Norditropin®, Novo Nordisk A/S, Denmark) therapy w...

Transport of farm animals is considered as a key stress factor including multiple stressors as handling or fasting. In humans, compounds for the IGF-system are affected by acute or critical illness or stress. We have asked, if compounds from the IGF-system also may have biomarker potential in farm animals. A total of 80 pigs were transported for 2 h from a commercial finishing farm to the slaughterhouse. Blood samples from 40 pigs were taken before (basal levels) and after shi...

Aim: İmpaired glucose tolerance and hyperinsulinism/insulin resistance frequently accompany by acromegaly. NLO (Neutrophile lymphocyte ratio) is demonstrated as a simple indicator of systemic inflammation and it is also known that NLO is associated with atherosclerosis progression in coronary artery and a risk factor in coroner artery disease. In this study, we intend to search the association between both coronary atherosclerosis seen frequently in patients diagnosed wi...

Background: OPKO Biologics is a clinical-stage public company developing long-acting therapeutic proteins utilizing CTP technology. The technology involves fusion of the C-terminus peptide of human chorionic gonadotropin (hCG), a highly O-glycosylated peptide, to the target protein. CTP enabled the production of a long-acting human growth hormone (hGH) (MOD-4023) that supports a single-weekly injection in growth hormone-deficient patients. MOD-4023 is manufactured as a non-vis...

Aim: The risk of cardiovascular mortality is high in patients with acromegaly. In this study, we intent to evaluate serum lipid profile in patients newly diagnosed with acromegaly and determine its association with increased growth hormone (gh) and insulin like growth factor-1 (igf-1) levels.Material and method: This study includes 57 patients newly diagnosed with acromegaly in our hospital (mean age 44.1±13.8 years; mean bmi 29.6±5.4 kg/m...

Aim: To study the frequency of growth hormone deficiency (GHD) in patients with nonfunctional pituitary tumors (NFPA).Materials and methods: Over a period of 1.0 year, we studied in our department retrospective data of 33 patients with pituitary tumors in terms of CT/MRI imaging and detailed hormonal functional assessment – STH, IGF-1, LH, FSH, ACTH, prolactin, TSH, cortisol, thyroxine. From the patients are 11 – men and 12 women, mean age of p...

Background: Impaired Insulin-like growth factor-1 (IGF-1) function is associated with obesity and hypertension, but the correlation of circulating IGF-1 with these conditions is weak. As a metabolite of IGF-1, the ratio of cGP/IGF-1 regulates IGF-1 bioavailability and may be a more accurate biomarker of IGF-1 function in obesity and hypertension.Methods: Using ELISA and HPLCms methodologies, we analysed plasma concentration of IGF-1, cGP and IGFBP-3 in 4...