Endocrine Abstracts

Context: Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide, affecting 2–8% of all pregnancies. We have previously shown that women with high-normal levels of FT4 during early pregnancy have a 2.1-fold increased risk of preeclampsia – but there was no apparent association with low TSH. However, the thyroid is stimulated by human chorionic gonadotropin (hCG) during early pregnancy and therefore we hypothesized that women with h...

The functional state of the thyroid is usually determined by thyrotropin (TSH), whose serum levels depend on circulating thyroid hormone (TH) levels. This feedback mechanism is tightly controlled in the individual and contrasts broad reference range for TSH in the general population, leading to the concept of subclinical thyroid disease. We studied a model of experimental thyrotoxicosis in humans employing an untargeted metabolome and proteome approach. This allowed us to gain...

Type 2 5’-deiodinase (DIO2) is a common enzyme between thyroid and eye muscle tissues involving in T4 conversion to T3. The role of DIO2 has been demonstrated in the development of skeletal muscle. Increased DIO2 activities was connected to eye muscle enlargements in hyperthyroid Graves’ ophthalmopathy. In this study, the presence of antibodies against human eye muscle tissue fractions with the binding to DIO2 peptide was investigated and measur...

Aim: Endocrine and metabolic disorders are among the most common complications in survivors after hematopoietic stem cell transplant (HSCT). The aim of this study was to evaluate thyroid function and glucose metabolism in patients treated with HSCT.Material and methods: This was a retrospective study which included 257 adult patients (173 males and 84 females) who underwent allogeneic HSCT between 2002 and 2014 in an Irish University Hospital. All patien...

Context: Identification of risk factors predicting relapse in patients with hyperthyroidism of Graves’ disease after the first cycle with standard thyreostatic therapy [ATD] is important to guide therapeutic options.Objective: We performed a systematic review and meta-analysis to study predictors for risk of relapse after the first treatment episode with ATD in patients with Graves’ disease induced hyperthyroidism.Data so...