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18th European Congress of Endocrinology

Oral Communications

Thyroid Cancer

ea0041oc14.1 | Thyroid Cancer | ECE2016

Tumor and normal thyroid stem-like cells: from tissues to zebrafish

Cirello Valentina , Vaira Valentina , Gaudenzi Germano , Stellaria Grassi Elisa , Vitale Giovanni , Ricca Dario , Bosari Silvano , Vicentini Leonardo , Persani Luca , Ferrero Stefano , Fugazzola Laura

Introduction: Cells with stem-like properties have been reported in benign and malignant thyroid diseases, and can be propagated by culturing them as non-adherent spheres.Design: Aim of the present study was to widely characterize the stem-like cells in tumor and normal thyroid tissues and in the corresponding in vitro-cultured thyrospheres, and to investigate in vivo the proangiogenic potential of thyrospheres in a zebrafish model....

ea0041oc14.2 | Thyroid Cancer | ECE2016

Complex immunometabolic pathways mediate the interaction between thyroid carcinoma cells and tumor-associated macrophages

Arts Rob , Plantinga Theo , Heinhuis Bas , Tuit Sander , Petrulea Mirela , Tesselaar Marika , Sloot Yvette , Kusters Benno , Joosten Leo , Georgescu Carmen , Smit Johannes , Netea Mihai , Schulze Joakim , Netea-Maier Romana

Background: Tumor-associated macrophages (TAMs) with dysregulated inflammatory phenotypes play a key role in carcinogenesis. In thyroid carcinoma (TC), excessive release of proinflammatory cytokines decreases the expression of sodium-iodine transporter and inflammation potentiates tumor progression.Aim: To assess the impact of TC cells on the functional reprograming of TC-induced macrophages at the level of transcriptome and metabolic pathways, and asses...

ea0041oc14.3 | Thyroid Cancer | ECE2016

Tert and the oxidative stress in papillary thyroid cancer

Muzza Marina , Colombo Carla , Cirello Valentina , Perrino Michela , Vicentini Leonardo , Fugazzola Laura

Abstract: During hormonogenesis, thyroid cells are physiologically exposed to high levels of reactive oxygen species (ROS) which could either be involved in the pathogenesis of thyroid cancer or exert a cytotoxic effect. We analyzed the oxidative status of papillary thyroid cancer (PTC) either directly, by measuring H2O2 generation by NADPH oxidases (NOXs), and indirectly, by evaluating the antioxidant activity of glutathione peroxidase (GPX), which neutr...

ea0041oc14.4 | Thyroid Cancer | ECE2016

Prognostic value of microscopic extrathyroid extension in papillary thyroid carcinoma

Marques Bernardo , Martins Raquel , Couto Joana , Santos Jacinta , Martins Teresa , Mesquita Pedro , Gilde Patricia , Portela Ivan , Rovira Eugenia , Oliveira Sofia , Cruz Carlos , Neto Joao , Rodrigues Fernando

Introduction: Although recognized as a risk factor in most staging systems, including the UICC TNM classification, the significance of microscopic extrathyroid extension (ETE) in papillary thyroid carcinoma (PTC) remains controversial. Despite this fact, its diagnosis by a pathologist following surgery for tumours ≤ 4 cm without metastases means an upstaging to pT3 and stage III in patients over 45 years, implying a poorer survival. Our study aimed to evaluate the impact...

ea0041oc14.5 | Thyroid Cancer | ECE2016

Clinical presentation, treatment and outcome of anaplastic thyroid carcinoma in Germany: a retrospective multi-center study

Wendler Julia , Kroiss Matthias , Gast Katja , Kreissl Michael , Allelein Stephanie , Lichtenauer Urs , Blaser Rainer , Kuhn Klaus , Spitzweg Christine , Fassnacht Martin , Fuhrer Dagmar , Schott Matthias , Tiedje Vera

Context: Anaplastic (ATC) thyroid carcinoma is an orphan disease accounting for about 2% of all malignant thyroid tumors. ATC confers a dismal prognosis and standard treatment is not established.Objective: To describe the epidemiology, current treatment regimens and outcome of ATC, to identify clinical prognostic markers and treatment factors associated with improved prognosis. To establish a consensus treatment schedule.Design: Re...