Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 41 | ECE2016 | Next issue

18th European Congress of Endocrinology

Guided Posters

Adrenal (1)

ea0041gp11 | Adrenal (1) | ECE2016

Adrenal hormones as independent predictor factors of mortality during sepsis or septic shock

De Castro Fernandez Rocio , Ruiz Ochoa David , Angel Lamsfus Prieto Jose , Alio Lavin Gomez Bernardo , Tejado Elviro Inigo , Marcano Rodriguez Gilberto , Santibanez Marguello Miguel

Introduction: Activation of the hypothalamic–pituitary–adrenal axis is critical for adaptation to stress and serious illness. The imbalance between anti-inflammatory activity of cortisol and proinflammatory activity of the androgens, dehydroepiandrosterone (DHEA) and dihydroepiandrosterone sulfate (DHEAS) can be an important predictor factor of mortality in sepsis.Material and methods: Patients diagnosed of severe sepsis or septic shock admitte...

ea0041gp12 | Adrenal (1) | ECE2016

Congenital adrenal hyperplasia (CAH) in adulthood

Vrbikova Jana , Frysak Zdenek , Cap Jan , Krcma Michal , Cifkova Renata , Lanska Vera

Background and aim: Up to now, there is paucity of studies concerning health status in adults with congenital adrenal hyperplasia (CAH). We aimed to examine a group of adult CAH patients from different Czech centers.Methods: Serum lipids, glucose, blood pressure and anhtropometrics were compared in 31 males and 71 females with CAH 21-hydroxylase deficiency and in healthy population from Czech post-MONICA study (1% random population sample).<p class="...

ea0041gp13 | Adrenal (1) | ECE2016

ACTH stimulation test (250 μg): is salivary cortisol an alternative to serum cortisol?

Albert Lara , Gimenez-Palop Olga , Capel Ismael , Miguel Gonzalez-Clemente Jose , Subias David , Sanchez-Delgado Jorge , Profitos Joaquim , Berlanga Eugenio , Casamitjana Laia , Rigla Mercedes

Introduction: Most serum cortisol (SeC) is linked to cortisol binding globulin and albumin. When the synthesis of proteins is reduced or increased, SeC does not reflect the actual free cortisol (FC) (active fraction). Methods for FC analysis are very laborious and expensive, which makes difficult to use them as a routine laboratory tests. Salivary cortisol (SaC) mirrors the FC in serum, being its measurement easier and cheaper. The determination of SaC, instead of tot...

ea0041gp14 | Adrenal (1) | ECE2016

A Phase 3b, open-label, extension study to evaluate the long-term safety of once-daily, dual-release hydrocortisone (DR-HC) in patients with adrenal insufficiency (AI)

Nilsson Anna , Bergthorsdottir Ragnhildur , Burman Pia , Dahlqvist Per , Ekman Bertil , Eden Engstrom Britt , Ragnarsson Oskar , Skrtic Stanko , Wahlberg Jeanette , Achenbach Heinrich , Uddin Sharif , Marelli Claudio , Johannsson Gudmundur

Introduction: Glucocorticoid replacement for adrenal insufficiency (AI) remains inadequate, resulting in high morbidity, premature mortality and quality-of-life (QoL) impairment. This study investigated the long-term safety of dual-release hydrocortisone (DR-HC) in patients with primary AI.Methods: AI patients who completed a randomized, 3-month crossover study of once-daily DR-HC versus thrice-daily conventional immediate-release hydrocortisone plus a 6...

ea0041gp15 | Adrenal (1) | ECE2016

Reduced temperature and the chemical chaperone 4-phenylbutyrate enhance stability of CYP21A2 mutations

Chen Yiqing , Schaefer Kerstin , Gasteiger Maria , Taylor Angela , Arlt Wiebke , Krone Nils , Gersting Soeren W. , Reisch Nicole

Background: Mutations of 21-hydroxylase (CYP21A2) cause congenital adrenal hyperplasia. Its severe (classic) form constitutes a life-threatening disease. Patients suffer a significant disease burden due to co-morbidities that are often treatment-related. The current therapeutic situation is unsatisfying and demands novel treatment approaches. In silico modelling suggests protein misfolding and intracellular retention to play a significant role in the pathogenesis of C...

ea0041gp16 | Adrenal (1) | ECE2016

Increased morbidity and hospital admissions in patients with adrenal insufficiency

Stewart Paul M , Biller Beverly MK , Marelli Claudio , Gunnarsson Candace , Ryan Michael , Johannsson Gudmundur

Introduction: Patients with adrenal insufficiency (AI) (primary (PAI), secondary to pituitary disease (PIT) and congenital adrenal hyperplasia (CAH)) have reduced life expectancy with reported standardized mortality ratios of ~2:1 but given the rarity of AI, the underlying explanation remains largely unknown.Objective: To evaluate patient characteristics, prevalence of concomitant conditions and hospitalization incidence in patients with AI compared to a...

ea0041gp17 | Adrenal (1) | ECE2016

Improved evening and nocturnal cortisol exposure time profile in patients with adrenal insufficiency treated with dual release hydrocortisone: correlation with improvement in metabolic profile

Simeoli Chiara , Ferrigno Rosario , De Martino Maria Cristina , Auriemma Renata Simona , Pivonello Claudia , Negri Mariarosaria , Iacuaniello Davide , Di Gennaro Gilda , Colao Annamaria , Pivonello Rosario

Conventional glucocorticoids (GCs) are unable to mimic physiological cortisol rhythm in adrenal insufficiency (AI), with a significant impact on morbidity and mortality. Possible explanations are supra-physiological doses and impaired cortisol profile. In particular, elevated evening cortisol levels were related to glucose tolerance and insulin sensitivity alterations and visceral obesity. Once-daily-dual-release-hydrocortisone (OD-DR-HC), better reproducing the physiological ...

ea0041gp18 | Adrenal (1) | ECE2016

Restoration of HPA axis is rapid in subclinical Cushing’s syndrome after adrenalectomy

Kim Hee Kyung , Jeong Yunah , Yoon Jee Hee , Kang Ho-Cheol

Objective: In subclinical Cushing’s syndrome (SC), it is assumed that glucocorticoid production is insufficient to cause a clinically recognizable syndrome. Differences in hormonal levels or recovery time of the hypothalamic–pituitary–adrenocortical (HPA) axis after adrenalectomy between patients with overt Cushing’s syndrome (OC) and SC remain unknown.Design and patients: Thirty seven patients (ten were OC and 27 were SC) with adrena...

ea0041gp19 | Adrenal (1) | ECE2016

MUC-1: update on a newly established tumor model for adrenocortical carcinoma

Hantel Constanze , Shapiro Igor , Jung Sara , Reincke Martin , Beuschlein Felix

In an attempt, to overcome the lack of preclinical models for adrenocortical carcinoma (ACC), we recently aimed at the development of patient-individual tumor models for ACC. During these studies one xenograft (MUC-1), derived from a neck metastasis of an ACC, showed extraordinary engraftment properties and sustained tumor growth over several passages in the murine host. During ongoing studies we investigated and compared all currently available xenograft models for ACC (NCI-H...

ea0041gp20 | Adrenal (1) | ECE2016

Responsiveness to hCG in postmenopausal women with adrenal adenomas

Popovic Bojana , Macut Djuro , Bozic-Antic Ivana , Bogavac Tamara , Ilic Dusan , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Damjanovic Svetozar

Introduction: Luteinizning hormone (LH/hCG) responsiveness has been documented in both normal and pathological adrenal glands, but it is unclear whether chronic exposure to LH could affect adrenal function by increasing LH receptor (LHR) expression.Subjects and methods: We studied 12 postmenopausal women with previously documented adrenal tumor. All patients underwent standard hormonal testing for assessment of tumor functionality. Then hCG test was perf...