Endocrine Abstracts

Introduction: Vitamin D insufficiency and deficiency are defined as a serum 25-hydroxy-vitamin D (25(OH)D) below 50 and 30 nmol/l respectively. We aimed to determine whether there is a serum 25(OH)D that signals a low serum calcium and phosphate, secondary hyperparathyroidism, high bone remodelling, low area bone mineral density (aBMD), and so, an increased risk for microstructural deterioration and bone fragility.Method: Concentrations of 25(OH)D, calci...

Introduction: Calcitriol-mediated hypercalcemia is one of the most common paraneoplastic syndromes associated with lymphoma.Aim: Evaluate clinical and biochemical manifestations as well on the management of hypercalcemia in patients with lymphoma.Materials and methods: Prospective analysis of patients with lymphoma who developed hypercalcemia during September-2011 and January-2016.Results: Two hundred and six...

Introduction: Parathyroid cancer (PC) is rare accounting for <1% of all presentations. Tumors that demonstrate these atypical features and do not fulfill criteria for carcinoma can be classified as atypical adenomas (APA). Herein we aimed to evaluate the clinical and biochemical features of the patients with an atypical parathyroid adenoma or carcinoma and compare it with benign parathyroid adenomas.Method: Twenty-eight patients who were operated for...

Introduction: Primary hyperparathyroidism (PHPT) results in alterations in carbohydrate metabolism, characterized by insulin resistance, hyperinsulinemia, and glucose intolerance.Objective: The aim of our study was to evaluate carbohydrate metabolism status in patients with PHPT.Methods: One hundred and nine patients with PHPT were investigated, healthy controls included 36 individuals matched by sex age and BMI (BMI=27±5 kg/m...

Introduction: Vitamin D insufficiency is very common among Spanish adults. It is well established there is an inverse relationship between vitamin D and PTH levels. The diagnostic approach of an increased serum PTH concentration in a normocalcemic normophosphatemic patient is frequent in routine practice and the deficiency of vitamin D is the major cause of secondary hyperparathyroidism (SHPT). The aims of this study were to evaluate the prevalence of SHPT in a cohort of normo...

Cinacalcet decreases and normalizes serum calcium levels across a broad severity range of primary hyperparathyroidism (PHPT), slightly reduces parathyroid hormone levels which generally remains elevated, whereas it has no effect on bone mineral density (BMD). Therefore, when administering cinacalcet to a patient with PHPT, concomitant treatment with an anti-catabolic drug should be considered.An open-labeled, prospective trial was conducted in 32 patient...

Introduction: Primary adult-type lactose malabsorption (PALM) is a widespread inherited autosomal recessive condition. It is considered to be associated with osteoporosis. The purpose of the present study was to assess the 25-hydroxy-vitamin D (25[OH]D) status, serum CrossLaps and dairy calcium intake in individuals with PALM (i.e., LCT C/C−13910 genotype) and normal controls (i.e., LCT C/T-13910 and T/T−13910 genotypes). I...

Objective: Sclerostin, a circulating Wnt antagonist and a main negative regulator of bone formation, is increased in type 2 diabetes (T2DM). No data are available on latent autoimmune diabetes in adults (LADA) and whether sclerostin is affected by metabolic syndrome (MS) associated with T2DM or LADA. We evaluated serum sclerostin and bone turnover markers in LADA and T2DM in relation with MS.Research design and methods: This cross-sectional study include...

Low maternal vitamin D (VD) status is associated with adverse fetal development. However gestational changes in VD metabolites and their relationship with cord concentrations are unclear.The plasma concentration of 25-hydroxyvitamin D3 (25(OH)D3) was measured using UPLC-MS/MS, and free 25(OH)D and vitamin D binding protein (DBP) concentrations were measured by ELISA. Plasma samples were collected longitudinally from women resident i...

Introduction: Patients with primary hyperparathyroidism (pHPT) run an increased risk of death, and in some studies cardiovascular diseases were inversely related to urine osmolality.Aim: Evaluate the renal concentration capacity in patients with mild and severe pHPT, and its changes after surgery for pHPT and during medical management and monitoring.Materials and methods: The study included 77 patients (median age 57 (52;61)) with ...