Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2016) 41 EP849 | DOI: 10.1530/endoabs.41.EP849

ECE2016 Eposter Presentations Paediatric endocrinology (8 abstracts)

Evaluation of creatine kinase levels during growth hormone treatment

Asan Onder , Fatma Budak & Zehra Aycan


Dr. Sami Ulus Gynecology and Obstetrics, Children Health and Diseases Training and Research Hospital, Pediatric Endocrinology Clinic, Ankara, Turkey.


Objective: To investigate the changes in serum creatine kinase (CK) levels during the treatment of patients with growth hormone (GH).

Methods: We evaluated 715 cases who were treated with GH retrospectively. The clinical data of 20 children with severe CK elevation (>500 IU/L) were analyzed.

Results: CK elevation was recorded in 96 of the cases (13.5%) during GH theraphy. 20 of these patients had severe CK elevation. The mean age of the cases with severe CK elevation was 11.5±3.4 years and mean serum CK level was 828.9±400.1 (504–2246) U/L. The time elapsed between the beginning of treatment and CK increase was 20.5±12.8 (3–48) months. 8 of the cases used GH formulations containing m-cresol. We found no significant differences in CK levels according to age, gender, height, growth velocity, diagnosis, lenght of the needle used and GH preparations.

Conclusion: Severe CK elevation was found in 2% of the patients on GH treatment. The effects of GH on muscle should be evaluated during follow up.

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