ECE2016 Guided Posters Diabetes (2) (10 abstracts)
The effect of glucose variability on microvascular complications in type 1 diabetes
Luís Cardoso 1 , Carla Baptista 1 , Dírcea Rodrigues 1, , Luísa Barros 1 , Daniela Guelho 1, , Nuno Vicente 1 , Diana Martins 1 , Diana Oliveira 1 , Adriana Lages 1 , Mara Ventura 1 & Francisco Carrilho 1
1Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 2Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Introduction: Evidence implicates oxidative stress as mediator of diabetic complications. Furthermore, glucose variability (GV) is associated with oxidative stress and inflammation; however, association between GV and diabetes complications remains to be established. Our aim was to assess GV in patients with and without microvascular complications (MVC).
Methods: We analysed 2454 and 6593 h of continuous glucose monitoring of patients with type 1 diabetes (T1D) and labile glucose control with or without MVC, respectively. Patients were matched for A1C. All data points were collected on iPro2™.
Most patients were females (n=36, 59%) and A1C was similar on both groups (7.7±0.9 vs 8.0±1.2%, P=0.372). Patients with MVC were older (36.9±4.8 vs 27.1±9.0 years, P<0.001) and had longer duration of T1D (22.7±6.1 vs 15.4±9.8 years, P=0.011) than patients without MVC. GV measured by standard deviation (3.5±0.8 vs 3.5±1.1, P=0.937), mean amplitude of glycaemic excursions (6.5±1.2 vs 6.8±2.5, P=0.716), mean of daily differences (3.8±0.9 vs 3.9±1.3, P=0.796) was similar between the patients with or without MVC, respectively. Interestingly, patients with neuropathy had higher GV measured by lability index (15.1±7.6 vs 6.1±3.6, P=0.02) and mean absolute glucose (3.4±0.9 vs 2.3±0.7, P=0.033) but they were significantly older (39.0 vs 29.3 years), had longer disease duration (27.0 vs 16.9 years) and poorer glycaemic control (A1C, 9.1 vs 7.9%) than patients without neuropathy.
Conclusion: GV was not consistently associated with higher burden of MVC. Though, prospectively designed studies targeting GV are needed to definitively clarify the importance of GV.
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Endocrine Abstracts
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