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Endocrine Abstracts (2016) 41 S22.1 | DOI: 10.1530/endoabs.41.S22.1

Sweden.


In humans and other mammalian species, follicular development is a complicated process. The pool of resting primordial follicles serves as the source of developing follicles and fertilizable ova for the entire length of female reproductive life. In recent years, molecular mechanisms underlying follicular activation and development have become more evident, mainly through the use of genetically modified mouse models. Recently reported mutant mouse models have shown that a synergistic and coordinated suppression of follicular activation provided by multiple inhibitory molecules is necessary to preserve the dormant follicular pool. Several molecules and pathways operating in both the somatic primordial follicle granulosa cells (pfGCs) and oocytes have been shown to be important for primordial follicle activation and development. In this presentation, we will summarize both historical and recent studies on mammalian primordial follicular activation and focus on the up-to-date knowledge of molecular networks controlling this important physiological event. These advances may provide a better understanding of human ovarian physiology and pathophysiology for future clinical applications.

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