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Endocrine Abstracts (2016) 41 S7.1 | DOI: 10.1530/endoabs.41.S7.1

The Netherlands.


Appropriate treatment of acromegaly results in biochemical control or cure and reduces signs and symptoms, morbidity and excess mortality. Nonetheless, many of these patients still have considerable decreases in quality of life parameters and suffer from increased morbidity due to combinations of factors, including pituitary insufficiency despite optimal endocrine substitution, irreversible effects of previous GH/IGF-1 excess with complex multisystem morbidity, and the effects of treatment modalities. Even during follow up after long term biochemical control or cure many of these patients suffer from the complications of previous GH/IGF-1 excess. These complications include sleep disorders, acromegalic cardiac manifestations, especially in older patients, acromegalic arthropathy (a distinct form of arthropathy) associated with arthralgias, aortic root dilatation, intracranial saccular aneurysms, dolichocolon, diverticular disease, and vertebral fractures despite normal bone density. Apparently, these long term manifestations of acromegaly have major irreversible components.

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