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Endocrine Abstracts (2016) 41 S9.3 | DOI: 10.1530/endoabs.41.S9.3

ECE2016 Symposia Bone marrow adipose tissue - A "novel" functionally active fat depot (3 abstracts)

Development, endocrine functions, and metabolism of marrow adipose tissues

Ormond A MacDougald


USA.


Marrow adipose tissue (MAT) accumulates in diverse clinical conditions but remains poorly understood. We have observed region-specific variation in MAT adipocyte development, regulation, size, lipid composition, gene expression and genetic determinants. Functionally, MAT is a disproportionate source of adiponectin. Early MAT formation in mice is conserved, whereas later development is strain dependent. Proximal, but not distal tibial, MAT is lost with 21-day cold exposure. Rat MAT adipocytes from distal sites have an increased proportion of monounsaturated fatty acids and expression of Scd1/Scd2, Cebpa and Cebpb. Humans also have increased distal marrow fat unsaturation. We define proximal ‘regulated’ MAT (rMAT) as single adipocytes interspersed with active haematopoiesis, whereas distal ‘constitutive’ MAT (cMAT) has low haematopoiesis, contains larger adipocytes, develops earlier and remains preserved upon systemic challenges. Loss of rMAT occurs in mice with congenital generalized lipodystrophy type 4, whereas both rMAT and cMAT are preserved in mice with congenital generalized lipodystrophy type 3. Consideration of these MAT subpopulations may be important for future studies linking MAT to bone biology, haematopoiesis and whole-body metabolism.

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