Searchable abstracts of presentations at key conferences in endocrinology
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Androgens 2016

ea0042il3 | Androgen Receptor | Androgens2016

Three-dimensional structure of homodimeric androgen receptor ligand-binding domain

Perpina Eva Estebanez

The first crystal structure of human androgen receptor (AR) homodimer will be presented. This structure allows for the structure-based rationalization of the largest number of disease-associated mutations described for the AR ligand binding domain (LBD), which have been involved in prostate cancer and androgen insensitivity syndromes. The conservation of essential residues involved in AR self-association in other oxosteroid receptors suggests a more common dimerization mechani...

ea0042il4 | Androgen Receptor | Androgens2016

Modulation of androgen receptor signaling in prostate cancer cells by SUMOylation and NFκB pathways

Palvimo Jorma J.

Transcriptional activity of androgen receptor (AR) is governed by androgenic ligands and (thought to be) fine-tuned by post-translational modifications, such as SUMOylation. We have utilized genome-wide tools to study in an unbiased fashion the role of SUMOylation in the regulation of AR-directed gene programs in prostate cancer cells. Our results show that the SUMOylation does not simply repress the AR activity, but the modification modulates the receptor activity in a target...