Endocrine Abstracts

The AR pathway accumulates myriad genomic and transcriptomic alterations during progression of prostate cancer to a lethal castration-resistant phenotype. The best characterized alterations are point mutations or amplification of the AR gene. More recently, our group had identified structural rearrangements in the AR gene as a novel class of alterations that occur frequently in castration-resistant prostate cancer (CRPC) tissues. AR gene rearrangements are associated with outl...