Endocrine Abstracts

Estrogen Receptor (ER) is the defining feature of luminal breast cancers, where is functions as a transcription factor. ER requires associated proteins to interact with the DNA, including the pioneer factors FoxA1 and GATA3, both of which mediate where in the genome ER resides. In the absence of FoxA1, ER binding and transcriptional activity is diminished, even in endocrine resistant contexts. We have utilized ChIP-seq in primary tumor material, coupled with functional analysi...