Endocrine Abstracts

Serum GH and IGF-I levels are closely correlated but discordance between GH and IGF-I levels can occur in patients with acromegaly either as a consequence of biological factors or as an artefact of the means of assessment or definitions of normality.Pegvisomant as a GH receptor antagonist lowers serum IGF-I but, due to negative feedback, increases GH levels. Raloxifene has been shown to lower IGF-I in men and women with acromegaly and oestrogen has been ...

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Pituitary disease covers a wide spectrum of conditions associated with considerable physical, psychological and cognitive manifestations, a number of which persist even after successful treatment of the pituitary gland disorder.Quality of life (QoL) is defined as ‘the functional effect of an illness and its consequent therapy upon a patient, as perceived by the patient’’. In the last years, the area of QoL in patients with pituitary diseas...