Endocrine Abstracts

Glucocorticoid receptor (GR) agonists are amongst the most effective anti-inflammatory drugs available. These drugs are used in the treatment of a wide range of inflammatory and autoimmune diseases, and for the clinical management of cancer and organ/tissue transplantation. Unfortunately, the full clinical potential of these drugs has not been achieved, especially upon chronic use, due to the occurrence of side effects and/or resistance. The past years, most attention has focu...

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The circadian clock is a key regulator of immune responses. Both circulating and resident immune cells possess intrinsic timers, which act to impart time-of-day variation in their function. It is now becoming evident that the circadian clock is also critically involved in regulating the function of endogenous anti-inflammatory glucocorticoid hormones. Consequently, we see variation in an animal’s inflammatory responses dependent on the time the stimulus was delivered. Thi...