Endocrine Abstracts

The early embryo before implantation, in addition to undergoing the intrinsic steps of morphogenesis, demonstrates external ’awareness’ of environmental conditions in particular maternal nutritional quality. These nutritional cues are used to optimise the developmental programme for long-term survival, a form of developmental plasticity. Thus, maternal protein restriction exclusively during mouse preimplantation development with normal nutrition thereafter and postna...

Although development is a highly organised and tightly regulated process, the developing embryo is sensitive to environmental influences, resulting in pathophysiological changes which may increase the risk of later cardio-metabolic, neurobehavioural and reproductive disorders. We have shown that prenatal overexposure to the synthetic glucocorticoid dexamethasone (Dex) in rats reduces birthweight in the first generation (F1) and leads to hypertension and insulin resistance in t...

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