Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2016

Brighton, UK
07 Nov 2016 - 09 Nov 2016

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07 Nov 2016 to 09 Nov 2016 Brighton, UK Further information

Oral Communications

Pregnancy and Reproductive Health

ea0044oc6.1 | Pregnancy and Reproductive Health | SFEBES2016

Two doses of kisspeptin improve oocyte maturation and implantation rates compared to a single kisspeptin injection during IVF treatment

Abbara Ali , Clarke Sophie , Islam Rumana , Prague Julia , Comninos Alexander , Narayanaswamy Shakunthala , Papadopolou Deborah , Roberts Rachel , Nesbitt Alexander , Izzi-Engbeaya Chioma , Vimalesvaran Sunitha , Ratnasabapathy Risheka , Salim Rehan , Lavery Stuart , Bloom Stephen , Trew Geoffrey , Dhillo Waljit

Background: In vitro fertilisation is an effective therapy for infertility, but can result in the potentially life-threatening complication, Ovarian Hyper-Stimulation Syndrome (OHSS). We have previously reported that a single injection of kisspeptin results in an LH surge of ~12–14 hrs duration, sufficient to safely induce oocyte maturation, but eliminate OHSS. However, the physiological LH surge in a normal menstrual cycle has a plateaux lasting 24–28 hrs. ...

ea0044oc6.2 | Pregnancy and Reproductive Health | SFEBES2016

The thyroidal response to hCG stimulation is impaired in women with subclinical hypothyroidism and is influenced by BMI, fetal sex and parity

Korevaar Tim , Chaker Layal , Visser Theo , Peeters Robin

Introduction: Although hCG is an important determinant of gestational thyroid function, it is unknown to what extent hCG is a risk factor for thyroid disease and we also lack knowledge on which characteristics influence the thyroidal response to hCG stimulation.Methods: hCG, TSH, FT4 and TPOAbs were measured in 5435 pregnant women (<18 weeks) in a prospective cohort. Subclinical disease entities were defined according to P2.5-P97.5 in TPOAb negative ...

ea0044oc6.3 | Pregnancy and Reproductive Health | SFEBES2016

Controlled Antenatal Thyroid Screening Study; Obstetric Outcomes

Taylor Peter , Lacey Arron , Thayer Daniel , Draman Mohd , Tabasum Arshiya , Muller Ilaria , Marsh Luke , Poacher Arwel , Roberts Aled , Ludgate Marian , Rees Alex , Boelaert Kristien , Rees Aled , Chan Shiao , Lazarus John , Nelson Scott , Vaidya Bijay , Okosieme Onyebuchi

Context: Suboptimal thyroid function in pregnancy is associated with adverse obstetric outcomes but it is unclear whether levothyroxine treatment, initiated during pregnancy is beneficial.Design & Participants: Retrospective analysis of the Controlled Antenatal Thyroid Screening (CATS) study with obstetric outcomes obtained through data-linkage in the Secure Anonymised Information Linkage (SAIL) databank. We studied 13,224 pregnant women; 12,608 had ...

ea0044oc6.4 | Pregnancy and Reproductive Health | SFEBES2016

Iodine nutritional status among pregnant women and their offspring in Northern Ireland (NI)

McMullan Paul , Hamill Lesley , McCance David , Woodside Jayne , Mullan Karen

Background: A re-emergence of mild iodine deficiency in the United Kingdom (UK) has been reported. A recent UK study suggested a dose dependent relationship between mild maternal deficiency and a number of childhood cognitive scores. The World Health Organisation defines sufficiency in a population as a median urinary iodine concentration (UIC) of ≥100 μg/l in non-pregnant women and infants and ≥150 μg/l during pregnancy. It also recommends a daily intake...

ea0044oc6.5 | Pregnancy and Reproductive Health | SFEBES2016

Human placental and fetal liver molecular transporters are affected by maternal smoking

Walker Natasha , Filis Panagiotis , Soffientini Ugo , Bellingham Michelle , O'Shaughnessy Peter , Fowler Paul

Introduction: The placenta interchanges nutrients, oxygen and waste between mother and fetus, acts as a gate-keeper to protect the fetus and creates an optimal endocrine environment to maintain the pregnancy. Placental insufficiency underpins common pregnancy complications (e.g. intrauterine growth restriction, preterm birth). Perturbed expression of molecular transporter proteins in the placental syncytiotrophoblast will affect fetal exposure to harmful drugs/xenobiotics such...

ea0044oc6.6 | Pregnancy and Reproductive Health | SFEBES2016

Defining the metabolic phenotype of peritoneal mesothelial cells from women with endometriosis

Ahmad Syed F , Carter Roderick N , Collins Frances , Greaves Erin , Morton Nicholas M , Saunders Philippa TK , Horne Andrew W

Endometriosis is a chronic oestrogen-dependent incurable inflammatory disorder, defined by the presence of endometrial-like tissue outside the uterine cavity that affects 6–10% of women of reproductive age. It is associated with debilitating pelvic pain and subfertility with a significant impact on quality of life and estimated annual costs to the UK of £11.7 billion. Recent findings from our laboratory have shown that there is a shift in cell metabolism from mitocho...